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乙醇胺:一种新型抗衰老剂。

Ethanolamine: A novel anti-aging agent.

作者信息

Rockenfeller Patrick, Carmona-Gutierrez Didac, Pietrocola Federico, Kroemer Guido, Madeo Frank

机构信息

Institute of Molecular Biosciences; NAWI Graz, University of Graz ; Graz, Austria.

Equipe 11 labellisée par la Ligue contre le Cancer; Centre de Recherche des Cordeliers; Paris, France; Cell Biology and Metabolomics Platforms; Gustave Roussy Comprehensive Cancer Center; Villejuif, France; INSERM; U1138; Paris, France.

出版信息

Mol Cell Oncol. 2015 Mar 19;3(1):e1019023. doi: 10.1080/23723556.2015.1019023. eCollection 2016 Jan.

DOI:10.1080/23723556.2015.1019023
PMID:27308532
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4845168/
Abstract

Ethanolamine (Etn) is a naturally occurring aminoalcohol necessary for synthesis of the phospholipid phosphatidylethanolamine (PE), a major component of biological membranes. We recently reported that Etn treatment increases cellular PE levels, thereby inducing cytoprotective autophagy and protecting against aging across species.

摘要

乙醇胺(Etn)是一种天然存在的氨基醇,是合成磷脂酰乙醇胺(PE)所必需的,而磷脂酰乙醇胺是生物膜的主要成分。我们最近报道,乙醇胺处理可提高细胞内PE水平,从而诱导具有细胞保护作用的自噬,并在不同物种中预防衰老。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4c0/4845168/d4f8173fbb43/kmco-03-01-1019023-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4c0/4845168/d4f8173fbb43/kmco-03-01-1019023-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4c0/4845168/d4f8173fbb43/kmco-03-01-1019023-g001.jpg

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1
Ethanolamine: A novel anti-aging agent.乙醇胺:一种新型抗衰老剂。
Mol Cell Oncol. 2015 Mar 19;3(1):e1019023. doi: 10.1080/23723556.2015.1019023. eCollection 2016 Jan.
2
Phosphatidylethanolamine synthesis in ethanolamine-responsive and -nonresponsive cells in culture.培养的乙醇胺反应性和非反应性细胞中磷脂酰乙醇胺的合成
J Cell Physiol. 1983 Oct;117(1):109-15. doi: 10.1002/jcp.1041170115.
3
The role of phosphatidylserine decarboxylase in brain phospholipid metabolism.磷脂酰丝氨酸脱羧酶在脑磷脂代谢中的作用。
J Neurochem. 1983 Nov;41(5):1445-54. doi: 10.1111/j.1471-4159.1983.tb00844.x.
4
Metabolic link between phosphatidylethanolamine and triacylglycerol metabolism in the yeast Saccharomyces cerevisiae.酿酒酵母中磷脂酰乙醇胺与三酰甘油代谢之间的代谢联系。
Biochim Biophys Acta. 2011 Dec;1811(12):1030-7. doi: 10.1016/j.bbalip.2011.08.007. Epub 2011 Aug 19.
5
Candida albicans Cannot Acquire Sufficient Ethanolamine from the Host To Support Virulence in the Absence of Phosphatidylethanolamine Synthesis.白色念珠菌无法从宿主中获取足够的乙醇胺来支持在缺乏磷脂酰乙醇胺合成的情况下的毒力。
Infect Immun. 2018 Jul 23;86(8). doi: 10.1128/IAI.00815-17. Print 2018 Aug.
6
Monoethanolamine-induced glucose deprivation promotes apoptosis through metabolic rewiring in prostate cancer.单乙醇胺诱导的葡萄糖剥夺通过代谢重排促进前列腺癌细胞凋亡。
Theranostics. 2021 Aug 27;11(18):9089-9106. doi: 10.7150/thno.62724. eCollection 2021.
7
Ethanolamine modulates DNA synthesis through epidermal growth factor receptor in rat primary hepatocytes.乙醇胺通过大鼠原代肝细胞中的表皮生长因子受体调节DNA合成。
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Effect of membrane phosphatidylethanolamine-deficiency/phosphatidylcholine-excess on the metabolism of phosphatidylcholine and phosphatidylethanolamine.膜磷脂酰乙醇胺缺乏/磷脂酰胆碱过量对磷脂酰胆碱和磷脂酰乙醇胺代谢的影响
J Cell Physiol. 1992 Dec;153(3):589-95. doi: 10.1002/jcp.1041530321.
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Evidence from engineering that decarboxylation of free serine is the major source of ethanolamine moieties in plants.来自工程学的证据表明,游离丝氨酸的脱羧作用是植物中乙醇胺部分的主要来源。
Plant Cell Physiol. 2003 Nov;44(11):1185-91. doi: 10.1093/pcp/pcg144.
10
Influence of Myo-inositol Plus Ethanolamine on Plasmalogens and Cell Viability during Oxidative Stress.肌醇加乙醇胺对氧化应激时磷脂酰乙醇胺和细胞活力的影响。
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本文引用的文献

1
Phosphatidylethanolamine positively regulates autophagy and longevity.磷脂酰乙醇胺正向调节自噬和寿命。
Cell Death Differ. 2015 Mar;22(3):499-508. doi: 10.1038/cdd.2014.219. Epub 2015 Jan 9.
2
Autophagy competes for a common phosphatidylethanolamine pool with major cellular PE-consuming pathways in Saccharomyces cerevisiae.在酿酒酵母中,自噬与主要的消耗细胞磷脂酰乙醇胺的途径竞争共同的磷脂酰乙醇胺库。
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The machinery of macroautophagy.巨自噬的机制。
暴露于慢性紫外线A或紫外线B辐射以及局部应用大麻二酚的大鼠皮肤角质形成细胞脂质谱的变化。
Antioxidants (Basel). 2020 Nov 25;9(12):1178. doi: 10.3390/antiox9121178.
4
Cannabidiol-Mediated Changes to the Phospholipid Profile of UVB-Irradiated Keratinocytes from Psoriatic Patients.大麻二酚对银屑病患者 UVB 照射角质形成细胞磷脂谱的影响。
Int J Mol Sci. 2020 Sep 9;21(18):6592. doi: 10.3390/ijms21186592.
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Can autophagy promote longevity?自噬能促进长寿吗?
Nat Cell Biol. 2010 Sep;12(9):842-6. doi: 10.1038/ncb0910-842.
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Induction of autophagy by spermidine promotes longevity.亚精胺诱导自噬可促进长寿。
Nat Cell Biol. 2009 Nov;11(11):1305-14. doi: 10.1038/ncb1975. Epub 2009 Oct 4.
6
Phosphatidylserine and phosphatidylethanolamine in mammalian cells: two metabolically related aminophospholipids.哺乳动物细胞中的磷脂酰丝氨酸和磷脂酰乙醇胺:两种代谢相关的氨基磷脂。
J Lipid Res. 2008 Jul;49(7):1377-87. doi: 10.1194/jlr.R700020-JLR200. Epub 2008 Jan 19.
7
Contribution of different pathways to the supply of phosphatidylethanolamine and phosphatidylcholine to mitochondrial membranes of the yeast Saccharomyces cerevisiae.不同途径对酿酒酵母线粒体膜磷脂酰乙醇胺和磷脂酰胆碱供应的贡献。
Biochim Biophys Acta. 2004 Nov 8;1686(1-2):161-8. doi: 10.1016/j.bbalip.2004.09.007.
8
Nonbilayer lipids affect peripheral and integral membrane proteins via changes in the lateral pressure profile.非双层脂质通过侧向压力分布的变化影响外周膜蛋白和整合膜蛋白。
Biochim Biophys Acta. 2004 Nov 3;1666(1-2):275-88. doi: 10.1016/j.bbamem.2004.06.010.
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A ubiquitin-like system mediates protein lipidation.一个类泛素系统介导蛋白质脂化。
Nature. 2000 Nov 23;408(6811):488-92. doi: 10.1038/35044114.