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大麻二酚对银屑病患者 UVB 照射角质形成细胞磷脂谱的影响。

Cannabidiol-Mediated Changes to the Phospholipid Profile of UVB-Irradiated Keratinocytes from Psoriatic Patients.

机构信息

Department of Analytical Chemistry, Medical University of Bialystok, Mickiewicza 2d, 15-222 Bialystok, Poland.

Faculty of Chemistry, University in Białystok, Ciołkowskiego 1K, 15-245 Białystok, Poland.

出版信息

Int J Mol Sci. 2020 Sep 9;21(18):6592. doi: 10.3390/ijms21186592.

DOI:10.3390/ijms21186592
PMID:32916896
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7555222/
Abstract

UVB phototherapy is treatment for psoriasis, which increases phospholipid oxidative modifications in the cell membrane of the skin. Therefore, we carried out lipidomic analysis on the keratinocytes of healthy individuals and patients with psoriasis irradiated with UVB and treated with cannabidiol (CBD), phytocannabinoid with antioxidant and anti-inflammatory properties. Our results showed that, in psoriatic keratinocytes phosphatidylcholine (PC), phosphatidylinositol (PI), phosphatidylserine (PS), and ether-linked phosphoethanolamine (PEo), were downregulated, while SM (d41:2) was upregulated. These changes were accompanied by an increase in negative zeta potential, which indicates translocation of PS to the outer layer of the membrane. CBD treatment of psoriatic keratinocytes led to downregulation of PC, PS, and upregulation of certain PEo and an SM species, SM (d42:2), and the zeta potential. However, UVB irradiation of psoriatic keratinocytes resulted in upregulation of PC, PC plasmalogens (PCp), PEo, and a decrease in the negative zeta potential. The exposure of UVB-irradiated cells to CBD led to a decrease in the level of SM (d42:2). Our results suggest that CBD induces pro-apoptotic mechanisms in psoriatic keratinocytes while simultaneously improving the antioxidant properties and preventing the loss of transepidermal water of keratinocytes of patients irradiated with UVB. Thus, CBD has potential therapeutic value in the treatment of psoriasis.

摘要

UVB 光疗是治疗银屑病的一种方法，它会增加皮肤细胞膜中磷脂的氧化修饰。因此，我们对健康个体和银屑病患者的角质形成细胞进行了脂质组学分析，这些细胞接受了 UVB 照射，并接受了大麻二酚（CBD）的治疗，CBD 是一种具有抗氧化和抗炎特性的植物大麻素。我们的研究结果表明，在银屑病角质形成细胞中，磷脂酰胆碱（PC）、磷脂酰肌醇（PI）、磷脂酰丝氨酸（PS）和醚连接的磷乙醇胺（PEo）下调，而 SM（d41：2）上调。这些变化伴随着负 ζ 电位的增加，这表明 PS 向膜的外层移位。CBD 处理银屑病角质形成细胞导致 PC、PS 下调，某些 PEo 和 SM 种类 SM（d42：2）上调，ζ 电位也上调。然而，UVB 照射银屑病角质形成细胞导致 PC、PC 质体（PCp）、PEo 上调，负 ζ 电位降低。暴露于 UVB 照射的细胞中的 CBD 导致 SM（d42：2）水平降低。我们的研究结果表明，CBD 在诱导银屑病角质形成细胞发生促凋亡机制的同时，还改善了抗氧化特性，并防止了接受 UVB 照射的患者角质形成细胞中经表皮水分的流失。因此，CBD 在治疗银屑病方面具有潜在的治疗价值。

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