扩展的MYC网络在癌细胞存活中的新作用。
A novel role for the extended MYC network in cancer cell survival.
作者信息
Carroll Patrick A, Diolaiti Daniel
机构信息
Division of Basic Sciences, Fred Hutchinson Cancer Research Center ; Seattle, WA, USA.
出版信息
Mol Cell Oncol. 2015 Apr 14;3(1):e1026528. doi: 10.1080/23723556.2015.1026528. eCollection 2016 Jan.
Abstract
Cancer cells exhibit altered metabolic requirements compared to their normal counterparts. This metabolic reprogramming is mediated by activation of oncogenes such as MYC. Here, we summarize our recent findings demonstrating a metabolic dependency of deregulated MYC on MLXIP-MLX, critical components of the nutrient-sensing arm of the extended MYC transcriptional network.
摘要
与正常细胞相比，癌细胞表现出代谢需求的改变。这种代谢重编程是由MYC等癌基因的激活介导的。在此，我们总结了我们最近的发现，这些发现表明失调的MYC对MLXIP-MLX存在代谢依赖性，MLXIP-MLX是扩展的MYC转录网络中营养感应臂的关键组成部分。
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