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本文引用的文献

1
NR2F1 controls tumour cell dormancy via SOX9- and RARβ-driven quiescence programmes.NR2F1通过SOX9和RARβ驱动的静止程序控制肿瘤细胞休眠。
Nat Commun. 2015 Jan 30;6:6170. doi: 10.1038/ncomms7170.
2
Characterization of single disseminated prostate cancer cells reveals tumor cell heterogeneity and identifies dormancy associated pathways.单个播散性前列腺癌细胞的特征分析揭示了肿瘤细胞的异质性，并确定了与休眠相关的途径。
Oncotarget. 2014 Oct 30;5(20):9939-51. doi: 10.18632/oncotarget.2480.
3
Mechanisms of disseminated cancer cell dormancy: an awakening field.播散性癌细胞休眠的机制：一个觉醒的领域。
Nat Rev Cancer. 2014 Sep;14(9):611-22. doi: 10.1038/nrc3793. Epub 2014 Aug 14.
4
TGF-β2 dictates disseminated tumour cell fate in target organs through TGF-β-RIII and p38α/β signalling.TGF-β2 通过 TGF-β-RIII 和 p38α/β 信号通路决定转移瘤细胞在靶器官中的命运。
Nat Cell Biol. 2013 Nov;15(11):1351-61. doi: 10.1038/ncb2861. Epub 2013 Oct 27.
5
Molecular regulation of stem cell quiescence.干细胞静止的分子调控。
Nat Rev Mol Cell Biol. 2013 Jun;14(6):329-40. doi: 10.1038/nrm3591.
6
Dormancy signatures and metastasis in estrogen receptor positive and negative breast cancer.雌激素受体阳性和阴性乳腺癌的休眠特征和转移。
PLoS One. 2012;7(4):e35569. doi: 10.1371/journal.pone.0035569. Epub 2012 Apr 18.
7
A gene signature identified using a mouse model of androgen receptor-dependent prostate cancer predicts biochemical relapse in human disease.利用雄激素受体依赖性前列腺癌小鼠模型鉴定的基因特征可预测人类疾病中的生化复发。
Int J Cancer. 2012 Aug 1;131(3):662-72. doi: 10.1002/ijc.26414. Epub 2012 Jan 24.
8
Bone morphogenetic protein 7 in dormancy and metastasis of prostate cancer stem-like cells in bone.骨形态发生蛋白 7 在前列腺癌干细胞样细胞骨内休眠和转移中的作用。
J Exp Med. 2011 Dec 19;208(13):2641-55. doi: 10.1084/jem.20110840. Epub 2011 Nov 28.
9
Cytokeratin-positive cells in the bone marrow and survival of patients with stage I, II, or III breast cancer.I、II或III期乳腺癌患者骨髓中的细胞角蛋白阳性细胞与生存情况
N Engl J Med. 2000 Feb 24;342(8):525-33. doi: 10.1056/NEJM200002243420801.
10
Chemoprevention in head and neck cancer: basic science and clinical application.头颈部癌症的化学预防：基础科学与临床应用
Semin Radiat Oncol. 1998 Oct;8(4):292-301. doi: 10.1016/s1053-4296(98)80027-1.

作为新兴抗转移治疗选择的休眠程序

Dormancy programs as emerging antimetastasis therapeutic alternatives.

作者信息

Sosa Maria Soledad

机构信息

Division of Hematology and Oncology; Department of Medicine; Icahn School Medicine at Mount Sinai; New York, NY USA; Tisch Cancer Institute, Mount Sinai School of Medicine; New York, NY USA.

出版信息

Mol Cell Oncol. 2015 Apr 14;3(1):e1029062. doi: 10.1080/23723556.2015.1029062. eCollection 2016 Jan.

DOI:10.1080/23723556.2015.1029062
PMID:27308542
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4845178/
Abstract

We recently published that the retinoid-responsive gene NR2F1 (nuclear receptor subfamily 2, group F, member 1) mediates postsurgical dormancy of local residual tumor cells and disseminated tumor cells. Importantly, the combination of azacytidine with retinoids induces dormancy of malignant tumor cells by reinstating the NR2F1-regulated gene program. These findings open the door to the development of strategies that may stop minimal residual disease from becoming life-threatening metastases.

摘要

我们最近发表了一项研究，指出类视黄醇反应基因NR2F1（核受体亚家族2，F组成员1）介导局部残留肿瘤细胞和播散性肿瘤细胞的术后休眠。重要的是，阿扎胞苷与类视黄醇联合使用可通过恢复NR2F1调控的基因程序来诱导恶性肿瘤细胞休眠。这些发现为开发可能阻止微小残留病发展为危及生命的转移瘤的策略打开了大门。