干细胞静止的分子调控。
Molecular regulation of stem cell quiescence.
机构信息
Paul F. Glenn Laboratories for the Biology of Aging, Stanford University School of Medicine, Stanford, California 94305, USA.
出版信息
Nat Rev Mol Cell Biol. 2013 Jun;14(6):329-40. doi: 10.1038/nrm3591.
Abstract
Subsets of mammalian adult stem cells reside in the quiescent state for prolonged periods of time. This state, which is reversible, has long been viewed as dormant and with minimal basal activity. Recent advances in adult stem cell isolation have provided insights into the epigenetic, transcriptional and post-transcriptional control of quiescence and suggest that quiescence is an actively maintained state in which signalling pathways are involved in maintaining a poised state that allows rapid activation. Deciphering the molecular mechanisms regulating adult stem cell quiescence will increase our understanding of tissue regeneration mechanisms and how they are dysregulated in pathological conditions and in ageing.
摘要
哺乳动物成体干细胞的亚群在很长一段时间内处于静止状态。这种状态是可逆的，长期以来一直被视为休眠状态，基本没有活性。最近在成体干细胞分离方面的进展提供了对静止状态的表观遗传、转录和转录后控制的深入了解，并表明静止状态是一种主动维持的状态，其中信号通路参与维持允许快速激活的平衡状态。解析调节成体干细胞静止的分子机制将增加我们对组织再生机制的理解，以及它们在病理条件和衰老中是如何失调的。
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