癌症相关成纤维细胞中的代谢重编程为肿瘤发生和转移扩散提供了一个生态位。
Metabolic rewiring in cancer-associated fibroblasts provides a niche for oncogenesis and metastatic dissemination.
作者信息
Liu Jingyi, Mi Jun, Zhou Binhua P
机构信息
The State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China; Department of Molecular and Cellular Biochemistry; Markey Cancer Center, University of Kentucky College of Medicine, Lexington, Kentucky, USA.
Department of Biochemistry & Molecular Cell Biology, Shanghai Key Laboratory of Tumor Microenvironment and Inflammation, Shanghai JiaoTong University School of Medicine , Shanghai, China.
出版信息
Mol Cell Oncol. 2015 Dec 14;3(1):e1056331. doi: 10.1080/23723556.2015.1056331. eCollection 2016 Jan-Feb.
Cancer-associated fibroblasts (CAFs) are major participants in the crosstalk between tumor cells and their microenvironment. CAFs provide not only multiple soluble factors but also metabolic fuels to promote tumor growth, invasion, and metastasis. We discuss recent developments delineating the effects of metabolic symbiosis between CAFs and tumor cells on tumor growth.
癌症相关成纤维细胞（CAFs）是肿瘤细胞与其微环境之间相互作用的主要参与者。CAFs不仅提供多种可溶性因子，还提供代谢燃料以促进肿瘤生长、侵袭和转移。我们讨论了描述CAFs与肿瘤细胞之间代谢共生对肿瘤生长影响的最新进展。
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