Palikaras Konstantinos, Lionaki Eirini, Tavernarakis Nektarios
Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Heraklion, Crete, Greece; Department of Biology, University of Crete, Heraklion, Crete, Greece.
Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas , Heraklion, Crete, Greece.
Mol Cell Oncol. 2015 Jun 10;3(1):e1056332. doi: 10.1080/23723556.2015.1056332. eCollection 2016 Jan.
Mitophagy is a conserved, mitochondria-specific autophagic clearance process. We recently discovered an intricate regulatory network that balances mitophagy with mitochondrial biogenesis. Proper coordination of these opposing processes is important for stress resistance and longevity. Nodal regulatory factors that contribute to mitochondrial homeostasis have also been linked to carcinogenesis, highlighting mitophagy as a potential target for therapeutic interventions against cancer.
线粒体自噬是一种保守的、线粒体特异性的自噬清除过程。我们最近发现了一个复杂的调控网络，该网络平衡了线粒体自噬与线粒体生物合成。这些相反过程的适当协调对于抗应激能力和寿命很重要。有助于线粒体稳态的关键调控因子也与癌症发生有关，这突出了线粒体自噬作为癌症治疗干预潜在靶点的重要性。
