线粒体自噬：疾病与健康状况下的表现
Mitophagy: In sickness and in health.
作者信息
Palikaras Konstantinos, Lionaki Eirini, Tavernarakis Nektarios
机构信息
Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, Heraklion, Crete, Greece; Department of Biology, University of Crete, Heraklion, Crete, Greece.
Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas , Heraklion, Crete, Greece.
出版信息
Mol Cell Oncol. 2015 Jun 10;3(1):e1056332. doi: 10.1080/23723556.2015.1056332. eCollection 2016 Jan.
Abstract
Mitophagy is a conserved, mitochondria-specific autophagic clearance process. We recently discovered an intricate regulatory network that balances mitophagy with mitochondrial biogenesis. Proper coordination of these opposing processes is important for stress resistance and longevity. Nodal regulatory factors that contribute to mitochondrial homeostasis have also been linked to carcinogenesis, highlighting mitophagy as a potential target for therapeutic interventions against cancer.
摘要
线粒体自噬是一种保守的、线粒体特异性的自噬清除过程。我们最近发现了一个复杂的调控网络，该网络平衡了线粒体自噬与线粒体生物合成。这些相反过程的适当协调对于抗应激能力和寿命很重要。有助于线粒体稳态的关键调控因子也与癌症发生有关，这突出了线粒体自噬作为癌症治疗干预潜在靶点的重要性。
相似文献
1
Mitophagy: In sickness and in health.线粒体自噬：疾病与健康状况下的表现
Mol Cell Oncol. 2015 Jun 10;3(1):e1056332. doi: 10.1080/23723556.2015.1056332. eCollection 2016 Jan.
2
Mitophagy and age-related pathologies: Development of new therapeutics by targeting mitochondrial turnover.自噬与年龄相关的病理学：通过靶向线粒体周转开发新的治疗方法。
Pharmacol Ther. 2017 Oct;178:157-174. doi: 10.1016/j.pharmthera.2017.04.005. Epub 2017 Apr 29.
3
Coupling mitogenesis and mitophagy for longevity.耦合有丝分裂和线粒体自噬以实现长寿。
Autophagy. 2015;11(8):1428-30. doi: 10.1080/15548627.2015.1061172.
4
Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans.线虫衰老过程中线粒体自噬和生物发生的协调作用。
Nature. 2015 May 28;521(7553):525-8. doi: 10.1038/nature14300. Epub 2015 Apr 20.
5
Novel Insights Into the Anti-aging Role of Mitophagy.对自噬的抗衰老作用的新认识。
Int Rev Cell Mol Biol. 2018;340:169-208. doi: 10.1016/bs.ircmb.2018.05.005. Epub 2018 Jun 20.
6
Mitochondrial homeostasis: the interplay between mitophagy and mitochondrial biogenesis.线粒体稳态：线粒体自噬与线粒体生物发生之间的相互作用。
Exp Gerontol. 2014 Aug;56:182-8. doi: 10.1016/j.exger.2014.01.021. Epub 2014 Jan 28.
7
Interfacing mitochondrial biogenesis and elimination to enhance host pathogen defense and longevity.连接线粒体生物合成与消除以增强宿主病原体防御和延长寿命。
Worm. 2015 Jul 29;4(3):e1071763. doi: 10.1080/21624054.2015.1071763. eCollection 2015 Jul-Sep.
8
Mitophagy, Mitochondrial Dynamics, and Homeostasis in Cardiovascular Aging.心血管衰老中的自噬、线粒体动力学和动态平衡。
Oxid Med Cell Longev. 2019 Nov 4;2019:9825061. doi: 10.1155/2019/9825061. eCollection 2019.
9
Mitophagy-promoting agents and their ability to promote healthy-aging.促进自噬的药物及其促进健康衰老的能力。
Biochem Soc Trans. 2023 Oct 31;51(5):1811-1846. doi: 10.1042/BST20221363.
10
Prohibitin 2 Is an Inner Mitochondrial Membrane Mitophagy Receptor. prohibitin 2是一种线粒体内膜线粒体自噬受体。
Cell. 2017 Jan 12;168(1-2):224-238.e10. doi: 10.1016/j.cell.2016.11.042. Epub 2016 Dec 22.
引用本文的文献
1
Retinal Autophagy for Sustaining Retinal Integrity as a Proof of Concept for Age-Related Macular Degeneration.视网膜自噬维持视网膜完整性作为年龄相关性黄斑变性的概念验证
Int J Mol Sci. 2025 Jun 16;26(12):5773. doi: 10.3390/ijms26125773.
2
Galectin-8 drives ERK-dependent mitochondrial fragmentation, perinuclear relocation and mitophagy, with metabolic adaptations for cell proliferation.半乳糖凝集素-8驱动依赖细胞外调节蛋白激酶（ERK）的线粒体碎片化、核周重新定位和线粒体自噬，并伴有细胞增殖的代谢适应性变化。
Eur J Cell Biol. 2025 Jun;104(2):151488. doi: 10.1016/j.ejcb.2025.151488. Epub 2025 Apr 4.
3
Sea Cucumber Viscera Processed by Protease Hydrolysis Combined with Fermentation Protect Caco-2 Cells against Oxidative Damage via Enhancing Antioxidant Capacity, Activating Nrf2/HO-1 Pathway and Improving Cell Metabolism.蛋白酶水解结合发酵处理的海参内脏通过增强抗氧化能力、激活Nrf2/HO-1通路和改善细胞代谢保护Caco-2细胞免受氧化损伤。
Antioxidants (Basel). 2024 Aug 14;13(8):988. doi: 10.3390/antiox13080988.
4
Mitophagy in renal interstitial fibrosis.肾间质纤维化中的自噬现象。
Int Urol Nephrol. 2024 Jan;56(1):167-179. doi: 10.1007/s11255-023-03686-y. Epub 2023 Jul 14.
5
Rescue of Mitochondrial Function in Hutchinson-Gilford Progeria Syndrome by the Pharmacological Modulation of Exportin CRM1.通过 CRM1 输出蛋白调节剂的药理学调节来拯救早老性综合征中的线粒体功能
Cells. 2023 Jan 10;12(2):275. doi: 10.3390/cells12020275.
6
Neuronal induction of BNIP3-mediated mitophagy slows systemic aging in .BNIP3 介导线粒体自噬诱导神经元减缓. 的全身衰老。
Nat Aging. 2022 Jun;2(6):494-507. doi: 10.1038/s43587-022-00214-y. Epub 2022 May 16.
7
Shikonin regulates autophagy via the AMPK/mTOR pathway and reduces apoptosis of human umbilical cord mesenchymal stem cells to improve survival in tissues surrounding brain contusion.紫草素通过AMPK/mTOR途径调节自噬，并减少人脐带间充质干细胞的凋亡，以提高脑挫伤周围组织的存活率。
Exp Ther Med. 2021 Dec;22(6):1475. doi: 10.3892/etm.2021.10910. Epub 2021 Oct 22.
8
Expression of Autophagy and Mitophagy Markers in Breast Cancer Tissues.自噬和线粒体自噬标志物在乳腺癌组织中的表达
Front Oncol. 2021 Aug 18;11:612009. doi: 10.3389/fonc.2021.612009. eCollection 2021.
9
The effect of revascularization on recovery of mitochondrial respiration in peripheral artery disease: a case control study.血管重建对周围动脉疾病中线粒体呼吸恢复的影响：一项病例对照研究。
J Transl Med. 2021 Jun 4;19(1):244. doi: 10.1186/s12967-021-02908-0.
10
17β-Estradiol Induces Mitophagy Upregulation to Protect Chondrocytes the SIRT1-Mediated AMPK/mTOR Signaling Pathway.17β-雌二醇通过 SIRT1 介导的 AMPK/mTOR 信号通路诱导细胞自噬上调以保护软骨细胞。
Front Endocrinol (Lausanne). 2021 Feb 3;11:615250. doi: 10.3389/fendo.2020.615250. eCollection 2020.
本文引用的文献
1
Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans.线虫衰老过程中线粒体自噬和生物发生的协调作用。
Nature. 2015 May 28;521(7553):525-8. doi: 10.1038/nature14300. Epub 2015 Apr 20.
2
Mitophagy and cancer.自噬与癌症。
Cancer Metab. 2015 Mar 26;3:4. doi: 10.1186/s40170-015-0130-8. eCollection 2015.
3
Pan-cancer genetic analysis identifies PARK2 as a master regulator of G1/S cyclins.泛癌基因分析确定PARK2为G1/S细胞周期蛋白的主要调节因子。
Nat Genet. 2014 Jun;46(6):588-94. doi: 10.1038/ng.2981. Epub 2014 May 4.
4
Hypoxia signaling pathways in cancer metabolism: the importance of co-selecting interconnected physiological pathways.肿瘤代谢中的缺氧信号通路：选择相互关联的生理通路的重要性。
Cancer Metab. 2014 Feb 4;2(1):3. doi: 10.1186/2049-3002-2-3.
5
Regulation and function of mitophagy in development and cancer.线粒体自噬在发育和癌症中的调控和功能。
Autophagy. 2013 Nov 1;9(11):1720-36. doi: 10.4161/auto.26550. Epub 2013 Sep 26.
6
Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect.Parkin，p53 的一个靶基因，介导了 p53 在葡萄糖代谢和瓦博格效应中的作用。
Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16259-64. doi: 10.1073/pnas.1113884108. Epub 2011 Sep 19.
7
Minireview: IGF, Insulin, and Cancer.综述：IGF、胰岛素与癌症。
Endocrinology. 2011 Jul;152(7):2546-51. doi: 10.1210/en.2011-0231. Epub 2011 May 3.
8
Autophagy in the pathogenesis of myelodysplastic syndrome and acute myeloid leukemia.自噬在骨髓增生异常综合征和急性髓系白血病发病机制中的作用。
Cell Cycle. 2011 Jun 1;10(11):1719-25. doi: 10.4161/cc.10.11.15673.
9
Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia.线粒体自噬是一种依赖缺氧诱导因子-1（HIF-1）的对缺氧的适应性代谢反应。
J Biol Chem. 2008 Apr 18;283(16):10892-903. doi: 10.1074/jbc.M800102200. Epub 2008 Feb 15.
10
HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors.人肿瘤中细胞死亡因子BNIP3和NIX缺氧诱导的HIF-1依赖性调控
Cancer Res. 2001 Sep 15;61(18):6669-73.
Zotero 插件