人血浆中磷脂酰乙醇胺氢过氧化物的稳定性

Stabilization of phosphatidylethanolamine hydroperoxides in human plasma.

作者信息

Terao J

机构信息

Research Institute for Food Science, Kyoto University, Japan.

出版信息

Biochim Biophys Acta. 1989 Jun 8;1003(2):221-4. doi: 10.1016/0005-2760(89)90261-0.

DOI:10.1016/0005-2760(89)90261-0

PMID:2730895

Abstract

When phosphatidylcholine hydroperoxides (PC-OOH) and phosphatidylethanolamine hydroperoxides (PE-OOH) were incubated in normal saline at 37 degrees C, PE-OOH were decomposed more rapidly than PC-OOH, possibly due to Fe2+-binding ability of their polar head-group. In human plasma, both phospholipid hydroperoxides were stable during incubation. Iron ion-trapping ability of plasma components should be responsible for the hydroperoxide-stabilizing effect.

摘要

当磷脂酰胆碱氢过氧化物（PC-OOH）和磷脂酰乙醇胺氢过氧化物（PE-OOH）在37℃的生理盐水中孵育时，PE-OOH的分解速度比PC-OOH更快，这可能是由于其极性头部基团具有Fe2+结合能力。在人血浆中，两种磷脂氢过氧化物在孵育过程中均保持稳定。血浆成分的铁离子捕获能力应是造成氢过氧化物稳定作用的原因。