Colebatch J G, Gandevia S C
Department of Neurology, Prince Henry Hospital and School of Medicine, University of New South Wales, Sydney, Australia.
Brain. 1989 Jun;112 ( Pt 3):749-63. doi: 10.1093/brain/112.3.749.
The strength of 12 muscle groups of the arm was measured to determine the distribution of upper motor neuron weakness in man. Three groups of subjects were studied: 14 intact volunteers (both sides recorded), 10 patients with unilateral arm paresis (both sides recorded) and 6 patients with severe paralysis of the arm (the 'intact' arm only measured). On the side contralateral to the causative lesion the pattern of weakness was not the same in all patients. Shoulder muscles were relatively spared while the wrist and finger flexors were relatively severely affected, the difference being statistically significant. In hemiparetic and hemiplegic patients the strength of muscles ipsilateral to the lesion was reduced compared with normal controls. These observations refine previous clinical descriptions of upper motor neuron weakness and have implications for its pathophysiology.
测量了手臂12个肌肉群的力量，以确定人类上运动神经元无力的分布情况。研究了三组受试者：14名健康志愿者（记录双侧）、10名单侧手臂轻瘫患者（记录双侧）和6名手臂严重瘫痪患者（仅测量“健康”侧）。在病因性病变对侧，并非所有患者的无力模式都相同。肩部肌肉相对未受影响，而腕部和手指屈肌受影响相对严重，差异具有统计学意义。与正常对照组相比，偏瘫和半身不遂患者病变同侧肌肉的力量有所降低。这些观察结果细化了对上运动神经元无力的先前临床描述，并对其病理生理学有一定启示。
