在安全辐照下提高纳米粒子光靶向的精确性。
Enhanced Precision of Nanoparticle Phototargeting in Vivo at a Safe Irradiance.
机构信息
Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care Medicine, Boston Children's Hospital, Harvard Medical School , 300 Longwood Avenue, Boston, Massachusetts 02115, United States.
Institute of Advanced Materials, School of Materials Science & Engineering, Nanjing University of Posts and Telecommunications , 9 Wenyuan Road, Nanjing 210023, P. R. China.
出版信息
Nano Lett. 2016 Jul 13;16(7):4516-20. doi: 10.1021/acs.nanolett.6b01730. Epub 2016 Jun 21.
A large proportion of the payload delivered by nanoparticulate therapies is deposited not in the desired target destination but in off-target locations such as the liver and spleen. Here, we demonstrate that phototargeting can improve the specific targeting of nanoparticles to tumors. The combination of efficient triplet-triplet annihilation upconversion (TTA-UC) and Förster resonance energy transfer (FRET) processes allowed in vivo phototargeting at a safe irradiance (200 mW/cm(2)) over a short period (5 min) using green light.
很大一部分纳米颗粒疗法所传递的有效载荷并不是沉积在期望的靶部位，而是沉积在肝和脾等非靶部位。在这里，我们证明光靶向可以提高纳米颗粒对肿瘤的特异性靶向。高效的三重态-三重态湮灭上转换（TTA-UC）和Förster 共振能量转移（FRET）过程的结合可以在短时间（5 分钟）内使用绿光在安全辐照度（200 mW/cm2）下进行体内光靶向。
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