Ha Eun Ju, Baek Jung Hwan, Lee Jeong Hyun, Kim Jae Kyun, Choi Young Jun, Sung Tae Yon, Kim Tae Yong
Department of Radiology, Ajou University School of Medicine, Wonchon-Dong, Yeongtong-Gu, Suwon, 443-380, Korea.
Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, 86 Asanbyeongwon-Gil, Songpa-gu, Seoul, 138-736, Korea.
Eur Radiol. 2017 Mar;27(3):1186-1194. doi: 10.1007/s00330-016-4461-9. Epub 2016 Jun 16.
To present the various complications of ultrasound (US)-guided core needle biopsy (CNB) of thyroid lesions in a large patient series.
From January 2008 to March 2013, 6,169 patients underwent US-guided CNB of 6,687 thyroid nodules at a single institution. We assessed the number and types of major and minor complications, and evaluated the factors associated with complications.
Overall, 53 complications were observed in 50 patients (0.81 %), including 4 major and 49 minor complications. The major complications were massive haematoma (n = 2), pseudoaneurysm (n = 1) and voice change leading to disability that lasted for more than 30 days (n = 1). The minor complications were small to moderate haematoma (n = 42), carotid injury (n = 2), voice change that recovered within 30 days (n = 3), tracheal puncture (n = 1) and dysphagia (n = 1). Oedema (n = 12), vertebral puncture (n = 3) and vasovagal reaction (n = 1) were recorded as side effects. The presence of a coprocedure was the only significant factor associated with complications after thyroid CNB (P = 0.023).
US-guided CNB of thyroid lesions was found in a large population to be a safe procedure with a low complication rate.
• The complication rate after US-guided CNB for thyroid lesions was 0.81 % (50/6,169). • The rate of major complications was 0.06 % (4/6,169). • Vascular injury was the most common complication (47/6,169; 0.76 %). • None of the patients experienced permanent problems resulting from complications.
在一个大型患者系列中呈现超声（US）引导下甲状腺病变粗针穿刺活检（CNB）的各种并发症。
2008年1月至2013年3月，6169例患者在单一机构接受了US引导下对6687个甲状腺结节的CNB。我们评估了主要和次要并发症的数量及类型，并评估了与并发症相关的因素。
总体而言，50例患者（0.81%）出现了53例并发症，包括4例主要并发症和49例次要并发症。主要并发症为大量血肿（n = 2）、假性动脉瘤（n = 1）以及导致残疾且持续超过30天的声音改变（n = 1）。次要并发症为小至中度血肿（n = 42）、颈动脉损伤（n = 2）、30天内恢复的声音改变（n = 3）、气管穿刺（n = 1）和吞咽困难（n = 1）。水肿（n = 12）、椎体穿刺（n = 3）和血管迷走神经反应（n = 1）被记录为副作用。联合操作的存在是甲状腺CNB后与并发症相关的唯一显著因素（P = 0.023）。
在大量人群中发现US引导下甲状腺病变CNB是一种安全的操作，并发症发生率低。
• US引导下甲状腺病变CNB后的并发症发生率为0.81%（50/6169）。• 主要并发症发生率为0.06%（4/6169）。• 血管损伤是最常见的并发症（47/6169；0.76%）。• 没有患者因并发症出现永久性问题。
