Síbl O, Veselý J, Ivasková E, Suchánková A
Cesk Otolaryngol. 1989 Mar;38(2):121-7.
The authors deal in their paper with the problem of nondifferentiated carcinoma in childhood. They draw attention to data in the literature which report an incidence of 1-15% and compare with these data their own experience according to which in 158 patients with carcinoma of the nasopharynx there were seven children. They emphasize the inexpressive character of symptoms and thus the relatively long time which elapses before causal anti-tumourous treatment is started in child patients. They emphasize the importance of a uniform diagnostic protocol where they accentuate the directoscopy of the Rosenmüller fossa, tympanometry, computed tomography and draw attention to the advantages of EBV serology and mapping according to the HLA system. As far as treatment is concerned, they recommend radiotherapy, supplemented by adjuvant administration of the transfer factor and Mitolactol. In the conclusion the authors emphasize the necessity of team work to ensure correct interpretation of results from the diagnostic sphere and to ensure treatment in the initial stages when therapy gives the most permanent results.
作者在其论文中探讨了儿童未分化癌的问题。他们提请注意文献中的数据，这些数据报告的发病率为1% - 15%，并将这些数据与他们自己的经验进行比较，根据他们的经验，在158例鼻咽癌患者中有7名儿童。他们强调症状缺乏特异性，因此儿童患者在开始进行病因性抗肿瘤治疗之前会经过相对较长的时间。他们强调统一诊断方案的重要性，在此方案中，他们着重指出了对罗森米勒窝进行直接镜检、鼓室图检查、计算机断层扫描，并提请注意EB病毒血清学和根据HLA系统进行图谱分析的优势。就治疗而言，他们推荐放疗，并辅以转移因子和米托蒽醌的辅助给药。在结论中，作者强调团队合作的必要性，以确保对诊断领域的结果进行正确解读，并确保在治疗能取得最持久效果的初始阶段进行治疗。
