细胞如何知道它们是什么形状？
How do cells know what shape they are?
作者信息
Kang Hui, Lew Daniel J
机构信息
Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC, 27710, USA.
出版信息
Curr Genet. 2017 Feb;63(1):75-77. doi: 10.1007/s00294-016-0623-1. Epub 2016 Jun 16.
Abstract
Studies on a yeast cell cycle checkpoint that can delay mitosis depending on whether cells have built a bud have identified a "sensor" that seems to recognize the organization of filament-forming septin proteins. Innovative work applying correlative light and platinum replica electron microscopy suggests that the informative septin organization involves parallel alignment of septin filaments, and another striking study shows that septin filaments prefer to populate membranes that have positive micron-scale curvature. Together, these findings suggest a model for how cells may monitor aspects of their own shape to influence cell behavior.
摘要
关于一种酵母细胞周期检查点的研究表明，该检查点可根据细胞是否已形成芽来延迟有丝分裂，研究还发现了一种“传感器”，它似乎能识别形成丝状的隔膜蛋白的组织形式。运用相关光学和铂复型电子显微镜的创新性研究表明，提供信息的隔膜蛋白组织形式涉及隔膜丝的平行排列，另一项引人注目的研究表明，隔膜丝更倾向于分布在具有正微米级曲率的膜上。这些发现共同提出了一个模型，用以解释细胞如何监测自身形状的各个方面以影响细胞行为。
相似文献
1
How do cells know what shape they are?细胞如何知道它们是什么形状？
Curr Genet. 2017 Feb;63(1):75-77. doi: 10.1007/s00294-016-0623-1. Epub 2016 Jun 16.
2
Interplay between septin organization, cell cycle and cell shape in yeast.酵母中septin蛋白组织、细胞周期与细胞形态之间的相互作用
J Cell Sci. 2005 Apr 15;118(Pt 8):1617-28. doi: 10.1242/jcs.02286. Epub 2005 Mar 22.
3
Interplay of septin amphipathic helices in sensing membrane-curvature and filament bundling. septin 两性螺旋的相互作用在感知膜曲率和丝束捆绑中。
Mol Biol Cell. 2021 Oct 1;32(20):br5. doi: 10.1091/mbc.E20-05-0303. Epub 2021 Jul 28.
4
Sensing a bud in the yeast morphogenesis checkpoint: a role for Elm1.在酵母形态发生检查点中感知一个芽：Elm1的作用
Mol Biol Cell. 2016 Jun 1;27(11):1764-75. doi: 10.1091/mbc.E16-01-0014. Epub 2016 Apr 6.
5
Structural insights into yeast septin organization from polarized fluorescence microscopy.通过偏振荧光显微镜对酵母隔膜蛋白组织的结构洞察。
Nature. 2006 Sep 28;443(7110):466-9. doi: 10.1038/nature05109.
6
Septin collar formation in budding yeast requires GTP binding and direct phosphorylation by the PAK, Cla4.出芽酵母中隔膜蛋白环的形成需要GTP结合以及PAK蛋白Cla4的直接磷酸化作用。
J Cell Biol. 2004 Mar 1;164(5):701-15. doi: 10.1083/jcb.200312070.
7
The anillin-related region of Bud4 is the major functional determinant for Bud4's function in septin organization during bud growth and axial bud site selection in budding yeast.Bud4中与缢痕蛋白相关的区域是其在芽殖酵母芽生长和轴向芽位选择过程中，对隔膜组织发挥功能的主要功能决定因素。
Eukaryot Cell. 2015 Mar;14(3):241-51. doi: 10.1128/EC.00268-14. Epub 2015 Jan 9.
8
The role of Bni5 in the regulation of septin higher-order structure formation.Bni5在隔膜蛋白高阶结构形成调控中的作用。
Biol Chem. 2015 Dec;396(12):1325-37. doi: 10.1515/hsz-2015-0165.
9
Phosphorylation-dependent septin interaction of Bni5 is important for cytokinesis.Bni5的磷酸化依赖性septin相互作用对胞质分裂很重要。
J Microbiol. 2007 Jun;45(3):227-33.
10
Requirement of Bni5 phosphorylation for bud morphogenesis in Saccharomyces cerevisiae.酿酒酵母中芽形态发生对Bni5磷酸化的需求。
J Microbiol. 2007 Feb;45(1):34-40.
引用本文的文献
1
Dysfunction of Telomeric Cdc13-Stn1-Ten1 Simultaneously Activates DNA Damage and Spindle Checkpoints.端粒 Cdc13-Stn1-Ten1 功能障碍同时激活 DNA 损伤和纺锤体检查点。
Cells. 2024 Sep 25;13(19):1605. doi: 10.3390/cells13191605.
2
Cyclophilin A Isomerisation of Septin 2 Mediates Abscission during Cytokinesis.亲环素 A 介导有丝分裂末期隔蛋白 2 的异构化从而促进胞质分裂。
Int J Mol Sci. 2023 Jul 4;24(13):11084. doi: 10.3390/ijms241311084.
3
Septin and actin contributions to endothelial cell-cell junctions and monolayer integrity.Septins和肌动蛋白对内皮细胞间连接及单层完整性的作用。
Cytoskeleton (Hoboken). 2023 Jul-Aug;80(7-8):228-241. doi: 10.1002/cm.21732. Epub 2022 Oct 17.
4
Junctional Localization of Septin 2 Is Required for Organization of Junctional Proteins in Static Endothelial Monolayers.衔接蛋白 2 的衔接定位对于静态血管内皮单层细胞中连接蛋白的组织是必需的。
Arterioscler Thromb Vasc Biol. 2021 Jan;41(1):346-359. doi: 10.1161/ATVBAHA.120.315472. Epub 2020 Nov 5.
5
SEPT7 Interacts with KIF20A and Regulates the Proliferative State of Neural Progenitor Cells During Cortical Development.SEPT7 与 KIF20A 相互作用，调节皮质发育过程中神经祖细胞的增殖状态。
Cereb Cortex. 2020 May 14;30(5):3030-3043. doi: 10.1093/cercor/bhz292.
6
Unconventional Cell Division Cycles from Marine-Derived Yeasts.海洋源酵母的非传统细胞分裂周期。
Curr Biol. 2019 Oct 21;29(20):3439-3456.e5. doi: 10.1016/j.cub.2019.08.050. Epub 2019 Oct 10.
7
Cla4 PAK-like kinase is required for pathogenesis, asexual/sexual development and polarized growth in Bipolaris maydis.Cla4 PAK 样激酶是玉米平脐蠕孢菌致病、无性/有性发育和极性生长所必需的。
Curr Genet. 2019 Oct;65(5):1229-1242. doi: 10.1007/s00294-019-00977-9. Epub 2019 Apr 26.
8
Messengers for morphogenesis: inositol polyphosphate signaling and yeast pseudohyphal growth.形态发生的信使：肌醇多磷酸盐信号转导与酵母假菌丝生长。
Curr Genet. 2019 Feb;65(1):119-125. doi: 10.1007/s00294-018-0874-0. Epub 2018 Aug 12.
9
Implications of maintenance of mother-bud neck size in diverse vital processes of Saccharomyces cerevisiae.在酿酒酵母的各种重要过程中，维持母-芽颈大小的意义。
Curr Genet. 2019 Feb;65(1):253-267. doi: 10.1007/s00294-018-0872-2. Epub 2018 Jul 31.
10
Septins regulate junctional integrity of endothelial monolayers.Septins 调节内皮细胞单层的连接完整性。
Mol Biol Cell. 2018 Jul 15;29(13):1693-1703. doi: 10.1091/mbc.E18-02-0136. Epub 2018 May 17.
本文引用的文献
1
Sensing a bud in the yeast morphogenesis checkpoint: a role for Elm1.在酵母形态发生检查点中感知一个芽：Elm1的作用
Mol Biol Cell. 2016 Jun 1;27(11):1764-75. doi: 10.1091/mbc.E16-01-0014. Epub 2016 Apr 6.
2
Micron-scale plasma membrane curvature is recognized by the septin cytoskeleton.微米级的质膜曲率可被丝状肌动蛋白细胞骨架识别。
J Cell Biol. 2016 Apr 11;213(1):23-32. doi: 10.1083/jcb.201512029. Epub 2016 Apr 4.
3
A Septin-Dependent Diffusion Barrier at Dendritic Spine Necks.树突棘颈部的一种依赖于Septin的扩散屏障。
PLoS One. 2014 Dec 10;9(12):e113916. doi: 10.1371/journal.pone.0113916. eCollection 2014.
4
Architecture and dynamic remodelling of the septin cytoskeleton during the cell cycle.细胞周期中septin细胞骨架的结构与动态重塑
Nat Commun. 2014 Dec 5;5:5698. doi: 10.1038/ncomms6698.
5
Septins 2, 7 and 9 and MAP4 colocalize along the axoneme in the primary cilium and control ciliary length.Septins 2、7 和 9 与 MAP4 一起沿轴丝定位于初级纤毛中，并控制纤毛长度。
J Cell Sci. 2013 Jun 15;126(Pt 12):2583-94. doi: 10.1242/jcs.111377. Epub 2013 Apr 9.
6
Morphogenesis and the cell cycle.形态发生与细胞周期。
Genetics. 2012 Jan;190(1):51-77. doi: 10.1534/genetics.111.128314.
7
New insights into the phylogenetic distribution and evolutionary origins of the septins.对 septins 的系统发生分布和进化起源的新认识。
Biol Chem. 2011 Aug;392(8-9):681-7. doi: 10.1515/BC.2011.086.
8
Septin structure and function in yeast and beyond.酵母及其他生物中 septin 的结构与功能。
Trends Cell Biol. 2011 Mar;21(3):141-8. doi: 10.1016/j.tcb.2010.11.006. Epub 2010 Dec 20.
9
A septin diffusion barrier at the base of the primary cilium maintains ciliary membrane protein distribution.初级纤毛底部的 septin 扩散屏障维持纤毛膜蛋白的分布。
Science. 2010 Jul 23;329(5990):436-9. doi: 10.1126/science.1191054. Epub 2010 Jun 17.
10
Role of Septin cytoskeleton in spine morphogenesis and dendrite development in neurons.Septin细胞骨架在神经元树突棘形态发生和树突发育中的作用。
Curr Biol. 2007 Oct 23;17(20):1752-8. doi: 10.1016/j.cub.2007.09.039. Epub 2007 Oct 11.
Zotero 插件