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基于年龄、疫苗接种状态和性别的差异，2017-2018 年季节中 H3N2 疫苗和季节性流感病毒株的抗体识别。

Differential Antibody Recognition of H3N2 Vaccine and Seasonal Influenza Virus Strains Based on Age, Vaccine Status, and Sex in the 2017-2018 Season.

机构信息

Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

出版信息

J Infect Dis. 2020 Sep 14;222(8):1371-1382. doi: 10.1093/infdis/jiaa289.

DOI:10.1093/infdis/jiaa289
PMID:32496543
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7488199/
Abstract

BACKGROUND: An antigenic mismatch between the vaccine and circulating H3N2 strains was hypothesized to contribute to the severity of the 2017-2018 season in North America. METHODS: Serum and nasal washes were collected from influenza positive and negative patients during the 2017-2018 season to determine neutralizing antibody (nAb) titers and for influenza virus sequencing, respectively. RESULTS: The circulating and vaccine H3N2 virus strains were different clades, with the vaccine strain being clade 3C.2a and the circulating viruses being 3C.2a2 or 3C.3a. At enrollment, both the H3N2 negative and positive patients had greater nAb titers to the egg-adapted vaccine virus compared to the cell-grown vaccine but the H3N2-negative population had significantly greater titers to the circulating 3C.2a2. Among H3N2-positive patients, vaccination, younger age, and female sex were associated with greater nAb responses to the egg-adapted vaccine H3N2 virus but not to the cell-grown vaccine or circulating viruses. CONCLUSIONS: For the 2017-2018 circulating viruses, mutations introduced by egg adaptation decreased vaccine efficacy. No increased protection was afforded by vaccination, younger age, or female sex against 2017-2018 circulating H3N2 viruses.

摘要

背景：人们推测，疫苗与流行的 H3N2 株之间的抗原错配导致了 2017-2018 年北美的流感季节较为严重。

方法：在 2017-2018 年的流感季节，分别从流感阳性和阴性患者的血清和鼻洗液中采集样本，以确定中和抗体（nAb）滴度并进行流感病毒测序。

结果：循环和疫苗 H3N2 病毒株属于不同的分支，疫苗株为 3C.2a 分支，而流行株为 3C.2a2 或 3C.3a。在入组时，H3N2 阴性和阳性患者的 nAb 滴度均高于对鸡蛋适应的疫苗病毒，而与细胞生长的疫苗相比，H3N2 阴性患者对循环的 3C.2a2 的滴度明显更高。在 H3N2 阳性患者中，接种疫苗、年龄较小和女性与对鸡蛋适应的疫苗 H3N2 病毒的更高 nAb 反应相关，但与细胞生长的疫苗或循环病毒无关。

结论：对于 2017-2018 年的流行病毒，鸡蛋适应引起的突变降低了疫苗的功效。接种疫苗、年龄较小或女性并没有对 2017-2018 年的循环 H3N2 病毒提供额外的保护。

相似文献

[1]
Differential Antibody Recognition of H3N2 Vaccine and Seasonal Influenza Virus Strains Based on Age, Vaccine Status, and Sex in the 2017-2018 Season.

J Infect Dis. 2020-9-14

[2]
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[10]
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[6]
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[9]
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[10]
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本文引用的文献

[1]
Characterizing Emerging Canine H3 Influenza Viruses.

PLoS Pathog. 2020-4-14

[2]
Comparison of Human H3N2 Antibody Responses Elicited by Egg-Based, Cell-Based, and Recombinant Protein-Based Influenza Vaccines During the 2017-2018 Season.

Clin Infect Dis. 2020-9-12

[3]
Comparison of vaccine effectiveness against influenza hospitalization of cell-based and egg-based influenza vaccines, 2017-2018.

Vaccine. 2019-8-22

[4]
Potential Antigenic Mismatch of the H3N2 Component of the 2019 Southern Hemisphere Influenza Vaccine.

Clin Infect Dis. 2020-5-23

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Host Factors Impact Vaccine Efficacy: Implications for Seasonal and Universal Influenza Vaccine Programs.

J Virol. 2019-10-15

[6]
Age-associated changes in the impact of sex steroids on influenza vaccine responses in males and females.

NPJ Vaccines. 2019-7-12

[7]
A Tale of Two Mutations: Beginning to Understand the Problems with Egg-Based Influenza Vaccines?

Cell Host Microbe. 2019-6-12

[8]
Preventing an Antigenically Disruptive Mutation in Egg-Based H3N2 Seasonal Influenza Vaccines by Mutational Incompatibility.

Cell Host Microbe. 2019-5-28

[9]
Epidemiology and timing of seasonal influenza epidemics in the Asia-Pacific region, 2010-2017: implications for influenza vaccination programs.

BMC Public Health. 2019-3-21

[10]
Derivation and Validation of a Clinical Decision Guideline for Influenza Testing in 4 US Emergency Departments.

Clin Infect Dis. 2020-1-1

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