糖化血红蛋白、糖化血清蛋白与白蛋白、果糖胺与胰岛素依赖型妊娠糖尿病患者24小时血糖谱的相关性

Correlation of HbA1C, glycated serum proteins and albumin, and fructosamine with the 24-h glucose profile of insulin-dependent pregnant diabetics.

作者信息

Suhonen L, Stenman U H, Koivisto V, Teramo K

机构信息

Department of Gynecology & Obstetrics, University Central Hospital, Helsinki, Finland.

出版信息

Clin Chem. 1989 Jun;35(6):922-5.

PMID:2731364

Abstract

To assess the value of various methods for long-term follow-up of diabetic patients, we compared the concentrations of fructosamine in serum with those of various glycated proteins: hemoglobin (HbA1C), total serum proteins (G-prot), and albumin (G-alb), assayed in 30 pregnant insulin-dependent diabetics every two weeks after initial determination of a 24-h blood glucose profile. HbA1C correlated best with the 24-h glucose profile during the succeeding 10-35 days (r = 0.65-0.68, P less than 0.001). G-prot and G-alb correlated nearly as well as HbA1C 10-20 days after the glucose profile (r = 0.54-0.64, P less than 0.01-0.001), but only weakly after 25-35 days. Values for fructosamine did not correlate significantly with the glucose profile 10-35 days after it (r = 0.23-0.36). Evidently the fructosamine assay is not an adequate alternative to HbA1C, G-alb, or G-prot as an index to long-term control of blood glucose in such patients.

摘要

为评估糖尿病患者长期随访的各种方法的价值，我们在首次测定24小时血糖谱后，每两周对30例妊娠胰岛素依赖型糖尿病患者的血清果糖胺浓度与各种糖化蛋白：血红蛋白（HbA1C）、总血清蛋白（G-prot）和白蛋白（G-alb）的浓度进行比较。在随后的10 - 35天内，HbA1C与24小时血糖谱的相关性最佳（r = 0.65 - 0.68，P < 0.001）。在血糖谱测定后的10 - 20天，G-prot和G-alb的相关性与HbA1C相近（r = 0.54 - 0.64，P < 0.01 - 0.001），但在25 - 35天后相关性较弱。果糖胺值在血糖谱测定后的10 - 35天与血糖谱无显著相关性（r = 0.23 - 0.36）。显然，在这类患者中，果糖胺测定作为血糖长期控制的指标，不足以替代HbA1C、G-alb或G-prot。