被RNA“手指”夹住：长链非编码RNA作用于信号转导通路
Pinched by RNA "fingers": Long noncoding RNAs hitting signal transduction pathways.
作者信息
Liu Bodu, Sun Lijuan, Song Erwei
机构信息
Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China; Key Laboratory of Gene Engineering of Ministry of Education, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, China.
Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
出版信息
Mol Cell Oncol. 2016 Mar 16;3(3):e1046582. doi: 10.1080/23723556.2015.1046582. eCollection 2016 May.
We have recently reported a long noncoding RNA that interacts with nuclear factor κB (NFκB) and represses NFκB activation by physically masking the phosphorylation site of inhibitor of NFκB (IκB). Our findings have revealed a new class of long noncoding RNAs (lncRNAs) that directly interact with proteins involved in signal transduction pathways and interfere with cell signaling. This implicates a potential strategy for the design of RNA-based targeted drugs.
我们最近报道了一种长链非编码RNA，它与核因子κB（NFκB）相互作用，并通过物理掩盖NFκB抑制因子（IκB）的磷酸化位点来抑制NFκB的激活。我们的研究结果揭示了一类新的长链非编码RNA（lncRNAs），它们直接与信号转导通路中涉及的蛋白质相互作用，并干扰细胞信号传导。这暗示了一种基于RNA的靶向药物设计的潜在策略。
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