Fricchione Jon, Greenberg Mark S, Spring Justin, Wood Nellie, Mueller-Pfeiffer Christoph, Milad Mohammed R, Pitman Roger K, Orr Scott P
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Department of Psychiatry and Psychotherapy, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
Psychophysiology. 2016 Sep;53(9):1343-51. doi: 10.1111/psyp.12687. Epub 2016 Jun 17.
A brief 10-min time delay between an initial and subsequent exposure to extinction trials has been found to impair memory reconsolidation in fear-conditioned rodents and humans, providing a potential means to reduce fearfulness in anxiety disorders and posttraumatic stress disorder (PTSD). The present study used videos of biologically prepared, conditioned stimuli (tarantulas) to test the efficacy of delayed extinction in blocking reconsolidation of conditioned fear in healthy young adults. Strong differential conditioning, measured by skin conductance, was observed among a screened subset of participants during acquisition. However, the delayed-extinction intervention failed to reduce reactivity to the conditioned stimulus paired with the extinction delay. These results are partially consistent with other recent, mixed findings and point to a need for testing other candidate interventions designed to interfere with the reconsolidation process.
研究发现，在对恐惧条件反射的啮齿动物和人类进行初次和后续消退试验之间，短暂延迟10分钟会损害记忆再巩固，这为减轻焦虑症和创伤后应激障碍（PTSD）中的恐惧提供了一种潜在方法。本研究使用了生物准备的条件刺激（狼蛛）视频，来测试延迟消退在阻断健康年轻成年人条件恐惧再巩固方面的效果。在习得过程中，通过皮肤电传导测量，在经过筛选的部分参与者中观察到了强烈的差异条件反射。然而，延迟消退干预未能降低与消退延迟配对的条件刺激的反应性。这些结果与最近其他一些复杂的研究结果部分一致，并表明需要测试其他旨在干扰再巩固过程的候选干预措施。
