Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 N. Torrey Pines Rd., La Jolla, CA 92037, USA; Universidad Católica San Antonio de Murcia (UCAM) Campus de los Jerónimos, 135, Guadalupe 30107, Murcia, Spain.
Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 N. Torrey Pines Rd., La Jolla, CA 92037, USA.
Cell. 2016 Jun 16;165(7):1572-1585. doi: 10.1016/j.cell.2016.05.043.
The understanding of human biology and how it relates to that of other species represents an ancient quest. Limited access to human material, particularly during early development, has restricted researchers to only scratching the surface of this inherently challenging subject. Recent technological innovations, such as single cell "omics" and human stem cell derivation, have now greatly accelerated our ability to gain insights into uniquely human biology. The opportunities afforded to delve molecularly into scarce material and to model human embryogenesis and pathophysiological processes are leading to new insights of human development and are changing our understanding of disease and choice of therapy options.
对人类生物学的理解以及它与其他物种的关系代表了一个古老的探索。在早期发育过程中,人类材料的获取受到限制,这使得研究人员只能触及这个具有挑战性的主题的表面。最近的技术创新,如单细胞“组学”和人类干细胞的衍生,极大地加速了我们深入了解独特的人类生物学的能力。这些机会使我们能够深入研究稀缺的材料,并对人类胚胎发生和病理生理过程进行建模,从而为人类发展提供新的见解,并改变我们对疾病的理解和治疗选择。