工程化多尺度结构有序性以获得高保真胚胎样结构和类器官。
Engineering multiscale structural orders for high-fidelity embryoids and organoids.
机构信息
Institute of Biomechanics and Medical Engineering, Department of Engineering Mechanics, Tsinghua University, Beijing 100084, China; State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, Yunnan 650500, China.
Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109, USA; Department of Cell & Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
出版信息
Cell Stem Cell. 2022 May 5;29(5):722-743. doi: 10.1016/j.stem.2022.04.003.
Embryoids and organoids hold great promise for human biology and medicine. Herein, we discuss conceptual and technological frameworks useful for developing high-fidelity embryoids and organoids that display tissue- and organ-level phenotypes and functions, which are critically needed for decoding developmental programs and improving translational applications. Through dissecting the layers of inputs controlling mammalian embryogenesis, we review recent progress in reconstructing multiscale structural orders in embryoids and organoids. Bioengineering tools useful for multiscale, multimodal structural engineering of tissue- and organ-level cellular organization and microenvironment are also discussed to present integrative, bioengineering-directed approaches to achieve next-generation, high-fidelity embryoids and organoids.
类胚胎和类器官在人类生物学和医学领域具有巨大的应用潜力。本文讨论了用于开发高保真类胚胎和类器官的概念和技术框架，这些类器官能够展示组织和器官水平的表型和功能，这对于解码发育程序和改进转化应用至关重要。通过剖析控制哺乳动物胚胎发生的多层次输入，我们回顾了在重建类胚胎和类器官的多尺度结构秩序方面的最新进展。本文还讨论了用于组织和器官水平细胞组织和微环境的多尺度、多模态结构工程的生物工程工具，以提出综合的、受生物工程指导的方法来实现下一代的、高保真的类胚胎和类器官。
Zotero 插件