DFG Research Center for Regenerative Therapies, Technische Universität Dresden Fetscherstrasse 105, 01307 Dresden, GERMANY.
Cell. 2016 Jun 16;165(7):1598-1608. doi: 10.1016/j.cell.2016.05.038.
Recent advances in limb regeneration are revealing the molecular events that integrate growth control, cell fate programming, and positional information to yield the exquisite replacement of the amputated limb. Parallel progress in several invertebrate and vertebrate models has provided a broader context for understanding the mechanisms and the evolution of regeneration. Together, these discoveries provide a foundation for describing the principles underlying regeneration of complex, multi-tissue structures. As such these findings should provide a wealth of ideas for engineers seeking to reconstitute regeneration from constituent parts or to elicit full regeneration from partial regeneration events.
肢体再生领域的最新进展揭示了分子事件，这些分子事件整合了生长控制、细胞命运编程和位置信息，从而产生了对截断肢体的精确替代。在几种无脊椎动物和脊椎动物模型中的平行进展为理解再生的机制和进化提供了更广泛的背景。这些发现共同为描述复杂多组织结构再生的原理提供了基础。因此，这些发现应该为工程师提供丰富的思路，他们希望从组成部分重建再生，或者从部分再生事件中引出完全再生。
