蝾螈肢体再生过程中的假定上皮-间充质转化：当前观点和未来研究。
Putative epithelial-mesenchymal transitions during salamander limb regeneration: Current perspectives and future investigations.
机构信息
Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, USA.
Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.
出版信息
Ann N Y Acad Sci. 2024 Oct;1540(1):89-103. doi: 10.1111/nyas.15210. Epub 2024 Sep 13.
Previous studies have implicated epithelial-mesenchymal transition (EMT) in salamander limb regeneration. In this review, we describe putative roles for EMT during each stage of limb regeneration in axolotls and other salamanders. We hypothesize that EMT and EMT-like gene expression programs may regulate three main cellular processes during limb regeneration: (1) keratinocyte migration during wound closure; (2) transient invasion of the stump by epithelial cells undergoing EMT; and (3) use of EMT-like programs by non-epithelial blastemal progenitor cells to escape the confines of their niches. Finally, we propose nontraditional roles for EMT during limb regeneration that warrant further investigation, including alternative EMT regulators, stem cell activation, and fibrosis induced by aberrant EMT.
先前的研究表明上皮-间充质转化（EMT）在蝾螈肢体再生中起作用。在这篇综述中，我们描述了 EMT 在蝾螈和其他蝾螈肢体再生的每个阶段中的可能作用。我们假设 EMT 和 EMT 样基因表达程序可能调节肢体再生过程中的三个主要细胞过程：（1）伤口闭合过程中角质形成细胞的迁移；（2） EMT 上皮细胞对残肢的短暂侵袭；（3）非上皮性芽基细胞利用 EMT 样程序逃避其龛位的限制。最后，我们提出了 EMT 在肢体再生中的非传统作用，这些作用值得进一步研究，包括 EMT 的替代调节因子、干细胞激活以及 EMT 异常引起的纤维化。
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