Environmental Monitoring and Assessment Section, Health Safety and Environment Group, Bhabha Atomic Research Centre, Mumbai, 400085, India.
Environ Sci Pollut Res Int. 2016 Sep;23(18):18789-99. doi: 10.1007/s11356-016-7070-x. Epub 2016 Jun 17.
Endocrine disrupting chemicals (EDCs) are responsible for inappropriate development and they alter the hormonal and homeostatic systems of organism. Phthalates (PAEs), bisphenol A (BPA) and other EDCs were monitored in surface sediments at different stations across Thane Creek, India. Analysis of PAEs was carried out using GC-MS technique, while BPA and other EDCs were analyzing on UPLC-PDA instrument. Di-n-butyl phthalate (DBP) had the highest concentration among all fourteen analyzed phthalates ranges between 0.13 and 0.4 mg kg(-1); and was detectable in all sediment samples. Strong correlation (r = 0.95, p < 0.01) was observed between total organic carbon (TOC, %) and total PAEs. BPA was also detected in all samples; average BPA concentration varies from 16.3 to 35.79 μg kg(-1) with mean value 25.15 μg kg(-1) dry weight of sediment. Synthetic EDCs such as 4-para-nonylphenol (NP) and 4-tert-octylphenol (OP) were also analyzed; and their average concentrations were founds to be 356.5 and 176 μg kg(-1), respectively. Estrone (E1), 17β-estradiol (E2), and 17α-ethinylestradiol (EE2) were the main contributors to the overall estradiol equivalent concentration (EEQs) in sediment, their average total percentage contributions is more than 90 %.
内分泌干扰化学物质 (EDCs) 是造成发育异常的原因，它们会改变生物体的激素和动态平衡系统。在印度 Thane 溪的不同站点的表层沉积物中监测到邻苯二甲酸酯 (PAEs)、双酚 A (BPA) 和其他 EDCs。使用 GC-MS 技术分析 PAEs，而 BPA 和其他 EDCs 在 UPLC-PDA 仪器上进行分析。在所有分析的 14 种邻苯二甲酸酯中，二正丁基邻苯二甲酸酯 (DBP) 的浓度最高，范围在 0.13 至 0.4 mg kg(-1)；并且在所有沉积物样品中都可检测到。总有机碳 (TOC，%) 与总 PAEs 之间存在很强的相关性 (r = 0.95，p < 0.01)。所有样品中均检测到 BPA；BPA 的平均浓度范围从 16.3 到 35.79 μg kg(-1)，平均值为 25.15 μg kg(-1) 沉积物干重。还分析了合成 EDC 如 4-对壬基苯酚 (NP) 和 4-叔辛基苯酚 (OP)；它们的平均浓度分别为 356.5 和 176 μg kg(-1)。雌酮 (E1)、17β-雌二醇 (E2) 和 17α-乙炔基雌二醇 (EE2) 是沉积物中雌二醇当量浓度 (EEQs) 的主要贡献者，它们的平均总百分比贡献超过 90%。
