Eisenbrandt D L, Nitschke K D
Mammalian and Environmental Toxicology Research Laboratory, Dow Chemical Company 48674.
Fundam Appl Toxicol. 1989 Apr;12(3):540-57. doi: 10.1016/0272-0590(89)90027-4.
The inhalation toxicity of the structural fumigant sulfuryl fluoride (SO2F2) was evaluated in rats and rabbits. Exposures for a preliminary 2-week study were 6 hr/day, 5 days/week, to 0, 100, 300, or 600 ppm SO2F2. Nine of ten rats at 600 ppm died or were moribund between the second and sixth exposures. Extensive kidney lesions were present in all rats exposed to 600 ppm, whereas only minimal renal changes were noted in rats at 300 ppm. Upper and lower respiratory tissues were inflamed in the single rat that survived the 2-week exposure to 600 ppm. Rabbits exposed to 600 ppm SO2F2 were hyperactive and one animal had a convulsion. Exposure to 300 or 600 ppm for 2 weeks resulted in vacuolation and/or malacia in the cerebrum of all rabbits and most of these rabbits also had moderate inflammation of nasal tissues; a few rabbits at 600 ppm had inflammation of the trachea or bronchi. A subsequent 13-week study evaluated rats and rabbits exposed to 0, 30, 100, or 300 ppm SO2F2 (337 ppm TWA for rabbits). Rabbits initially were exposed to a high concentration of 600 ppm; however, convulsions were noted in two animals after nine exposures and the concentration subsequently was reduced to 300 ppm. Vacuolation and/or malacia were observed in the cerebrum of all rabbits at the highest concentration; one rabbit exposed to 100 ppm also had cerebral vacuolation. Rabbits at the highest concentration, as well as one rabbit exposed to 100 ppm, had inflammation of the nasal tissues. Rats exposed to 300 ppm SO2F2 for 13 weeks had mottled incisor teeth, minimal renal effects, pulmonary histiocytosis, inflammation of nasal tissues, and cerebral vacuolation. Also, rats exposed to 100 ppm SO2F2 for 13 weeks had mottled teeth. Fluoride toxicity was suggested by mottled teeth in rats as well as elevation of serum fluoride levels in rats and rabbits exposed to SO2F2 for 13 weeks. Although repeated exposure of rats and rabbits to 100-600 ppm SO2F2 resulted in toxicity of the kidneys (rats only), brain, and respiratory system, no effects were detected in animals exposed to 30 ppm for 13 weeks.
对大鼠和兔子评估了结构熏蒸剂硫酰氟（SO₂F₂）的吸入毒性。在初步的为期2周的研究中，暴露条件为每天6小时，每周5天，暴露于0、100、300或600 ppm的SO₂F₂。在600 ppm组的10只大鼠中，有9只在第二次至第六次暴露之间死亡或濒死。所有暴露于600 ppm的大鼠都出现了广泛的肾脏病变，而300 ppm组的大鼠仅观察到轻微的肾脏变化。在2周暴露于600 ppm后存活的唯一一只大鼠中，上、下呼吸道组织出现炎症。暴露于600 ppm SO₂F₂的兔子表现为多动，有一只动物发生惊厥。暴露于300或600 ppm 2周导致所有兔子大脑出现空泡化和/或软化，并且这些兔子中的大多数还伴有鼻腔组织中度炎症；600 ppm组的几只兔子有气管或支气管炎症。随后的为期13周的研究评估了暴露于0、30、100或300 ppm SO₂F₂（兔子的时间加权平均浓度为337 ppm）的大鼠和兔子。兔子最初暴露于600 ppm的高浓度；然而，在9次暴露后，有两只动物出现惊厥，随后浓度降至300 ppm。在最高浓度组的所有兔子大脑中均观察到空泡化和/或软化；一只暴露于100 ppm的兔子大脑也有空泡化。最高浓度组的兔子以及一只暴露于100 ppm的兔子有鼻腔组织炎症。暴露于300 ppm SO₂F₂ 13周的大鼠出现斑驳的门齿、轻微的肾脏影响、肺组织细胞增多症、鼻腔组织炎症和大脑空泡化。此外，暴露于100 ppm SO₂F₂ 13周的大鼠有斑驳的牙齿。大鼠的斑驳牙齿以及暴露于SO₂F₂ 13周的大鼠和兔子血清氟水平升高提示氟中毒。尽管大鼠和兔子反复暴露于100 - 600 ppm SO₂F₂会导致肾脏（仅大鼠）、大脑和呼吸系统中毒，但暴露于30 ppm 13周的动物未检测到任何影响。
