Lee M G, Thirumalai C H, Terry S I, Serjeant G R
Department of Medicine, University of the West Indies, Kingston, Jamaica.
Gut. 1989 May;30(5):569-72. doi: 10.1136/gut.30.5.569.
Upper endoscopic and gastric acid output studies were done in 51 patients with homozygous sickle cell (SS) disease and recurrent epigastric pain. Twenty (39%) had abnormalities in the upper gastrointestinal tract including 18 (35%) with peptic ulcers. Mean basal and maximum acid output were similar in patients with and without duodenal ulcer (DU). Because DU in SS disease does not appear to be associated with high acid outputs observed in other populations, it may reflect reduced mucosal resistance, possibly resulting from ischaemia. This hypothesis was supported by the significantly lower fetal haemoglobin level among SS-DU patients.
对51例纯合子镰状细胞（SS）病且有反复上腹部疼痛的患者进行了上消化道内镜检查和胃酸分泌研究。20例（39%）上消化道有异常，其中18例（35%）有消化性溃疡。有十二指肠溃疡（DU）和无十二指肠溃疡的患者的平均基础胃酸分泌量和最大胃酸分泌量相似。由于SS病中的DU似乎与其他人群中观察到的高胃酸分泌量无关，它可能反映了黏膜抵抗力降低，这可能是由局部缺血导致的。SS-DU患者中胎儿血红蛋白水平显著较低支持了这一假说。
