Kurth Sophie, Majerus Steve, Bastin Christine, Collette Fabienne, Jaspar Mathieu, Bahri Mohamed Ali, Salmon Eric
GIGA-Cyclotron Research Center In Vivo Imaging, University of Liège, Liège, Belgium.
Psychology and Neuroscience of Cognition Research Unit (PsyNCog): University of Liège, Liège, Belgium.
Neurobiol Aging. 2016 Aug;44:85-95. doi: 10.1016/j.neurobiolaging.2016.04.015. Epub 2016 Apr 28.
Interactions between a dorsal attention network (DAN) and a ventral attention cerebral network (VAN) have been reported in young participants during attention or short-term memory (STM) tasks. Because it remains an underinvestigated question, age effects on DAN and VAN activity and their functional balance were explored during performance of an STM task. Older and younger groups showed similar behavioral patterns of results. At the cerebral level, DAN activation increased as a function of increasing STM load in both groups, suggesting preserved activity in DAN during healthy aging. Age-related over-recruitment in regions of the DAN in the higher task load raised the question of compensation attempt versus less efficient use of neural resources in older adults. Lesser decrease of VAN activation with increasing load and decreased stimulus-driven activation in the VAN, especially in the higher load, in older participants suggested age-related reduced response in the VAN. However, functional connectivity measures showed that VAN was still functionally connected to the DAN in older participants.
据报道，在年轻参与者进行注意力或短期记忆（STM）任务时，背侧注意力网络（DAN）和腹侧注意力脑网络（VAN）之间存在相互作用。由于这仍是一个研究不足的问题，因此在进行STM任务期间，探讨了年龄对DAN和VAN活动及其功能平衡的影响。老年组和年轻组表现出相似的行为结果模式。在脑水平上，两组中DAN的激活均随着STM负荷的增加而增加，这表明在健康衰老过程中DAN的活动得以保留。在较高任务负荷下，DAN区域与年龄相关的过度激活引发了一个问题，即老年人是在尝试进行补偿还是对神经资源的利用效率较低。随着负荷增加，老年参与者中VAN激活的下降幅度较小，且VAN中刺激驱动的激活减少，尤其是在较高负荷时，这表明VAN的反应与年龄相关的降低。然而，功能连接性测量表明，老年参与者中VAN仍与DAN功能相连。
