Lee JuHee, Choi MoonKi, Yoo Yonju
1 Yonsei University, Seodaemun-gu, Seoul, Korea.
2 University of Virginia, Charlottesville, VA, USA.
Clin Nurs Res. 2017 Oct;26(5):608-631. doi: 10.1177/1054773816655091. Epub 2016 Jun 17.
Nonpharmacological interventions are important in providing care for Parkinson's disease (PD) patients. However, there is limited evidence related to their impacts on health-related quality of life (HRQOL). We aimed to examine the effectiveness of nonpharmacological interventions for improving the HRQOL of PD patients. Articles published in peer-reviewed journals from 2000 to 2015 were searched through electronic searching, computerized author searching, and footnote chasing. A meta-analysis was performed using the RevMan 5.3 program. Overall, effect size for the studies ( n = 18) was -4.17 with 95% confidence interval (CI) from -7.63 to -0.70 ( Z = 2.36, p = .02), indicating positive effects of nonpharmacological interventions on HRQOL. In subgroup analysis regarding the intervention types, the effect size of exercise programs was -5.73 with 95% CI of -11.36 to -0.10 ( Z = 2.00, p = .05). Thus, nonpharmacological interventions, and particularly exercise programs, were effective in improving the HRQOL of PD patients.
非药物干预在为帕金森病（PD）患者提供护理方面很重要。然而，关于其对健康相关生活质量（HRQOL）影响的证据有限。我们旨在研究非药物干预对改善PD患者HRQOL的有效性。通过电子检索、计算机化作者检索和参考文献追踪，检索了2000年至2015年发表在同行评审期刊上的文章。使用RevMan 5.3程序进行荟萃分析。总体而言，研究（n = 18）的效应大小为-4.17，95%置信区间（CI）为-7.63至-0.70（Z = 2.36，p = 0.02），表明非药物干预对HRQOL有积极影响。在关于干预类型的亚组分析中，运动计划的效应大小为-5.73，95%CI为-11.36至-0.10（Z = 2.00，p = 0.05）。因此，非药物干预，尤其是运动计划，在改善PD患者的HRQOL方面是有效的。
