Vordermark Dirk, Horsman Michael R
Universitätsklinik und Poliklinik für Strahlentherapie, Martin-Luther-Universität Halle-Wittenberg, Halle/Saale, Germany.
Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark.
Recent Results Cancer Res. 2016;198:123-42. doi: 10.1007/978-3-662-49651-0_6.
Tumor hypoxia is a clinically relevant cause of radiation resistance. Direct measurements of tumor oxygenation have been performed predominantly with the Eppendorf histograph and these have defined the reduced prognosis after radiotherapy in poorly oxygenated tumors, especially head-and-neck cancer, cervix cancer and sarcoma. Exogenous markers have been used for immunohistochemical detection of hypoxic tumor areas (pimonidazole) or for positron-emission tomography (PET) imaging (misonidazole). Overexpression of hypoxia-related proteins such as hypoxia-inducible factor-1α (HIF-1α) has also been linked to poor prognosis after radiotherapy and such proteins are considered as potential endogenous hypoxia markers.
肿瘤缺氧是导致放射抗性的一个临床相关因素。肿瘤氧合的直接测量主要通过Eppendorf组织血氧计进行，这些测量已经明确了在氧合不良的肿瘤（尤其是头颈癌、宫颈癌和肉瘤）放疗后预后较差。外源性标记物已被用于免疫组化检测缺氧肿瘤区域（匹莫硝唑）或正电子发射断层扫描（PET）成像（米索硝唑）。缺氧相关蛋白如缺氧诱导因子-1α（HIF-1α）的过表达也与放疗后的不良预后有关，这些蛋白被认为是潜在的内源性缺氧标记物。
