Grunwald J E, Furubayashi C
Scheie Eye Institute, Department of Ophthalmology, School of Medicine, University of Pennsylvania, Philadelphia 19104.
Invest Ophthalmol Vis Sci. 1989 Jun;30(6):1095-100.
The effects of topical timolol maleate 0.5% on the ophthalmic artery diastolic (OABPd), systolic (OABPs) and mean blood pressure (OABPm) were investigated in 19 healthy subjects using compression ophthalmodynamometry. In a randomized, double-blind study, one eye of each subject received one drop of timolol maleate 0.5% and the fellow eye received a drop of placebo. Measurements of OABPd and OABPs were performed just prior to instillation of the drops, and then 2 hr later. OABPm was calculated as OABPm = OABPd + 1/3 (OABPs - OABPd). No significant changes in OABPd, OABPs or OABPm were observed following the drops in the timolol-treated eyes or in the placebo-treated eyes. A significant difference (P = 0.0198) was found, however, when the changes in OABPm occurring in the timolol-treated eyes were compared with the changes occurring in the placebo-treated eyes, suggesting that the drug may have an effect upon ophthalmic artery pressure and retinal artery pressure that is expressed differently in each eye.
采用压迫式眼压计，对19名健康受试者研究了0.5%马来酸噻吗洛尔滴眼液对眼动脉舒张压（OABPd）、收缩压（OABPs）和平均血压（OABPm）的影响。在一项随机双盲研究中，每位受试者的一只眼睛滴入一滴0.5%马来酸噻吗洛尔滴眼液，另一只眼睛滴入一滴安慰剂。在滴入滴眼液之前以及之后2小时测量OABPd和OABPs。OABPm的计算方式为OABPm = OABPd + 1/3（OABPs - OABPd）。在滴入噻吗洛尔治疗眼或安慰剂治疗眼的滴眼液后，未观察到OABPd、OABPs或OABPm有显著变化。然而，当比较噻吗洛尔治疗眼OABPm的变化与安慰剂治疗眼OABPm的变化时，发现存在显著差异（P = 0.0198），这表明该药物可能对眼动脉血压和视网膜动脉血压有影响，且在每只眼睛中的表现有所不同。
