Yan Na, Fan Chengming, Chen Yuhong, Hu Zanmin
Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.
University of Chinese Academy of Sciences, Beijing 100049, China.
Int J Mol Sci. 2016 Jun 17;17(6):962. doi: 10.3390/ijms17060962.
As photosynthetic organisms, microalgae can efficiently convert solar energy into biomass. Microalgae are currently used as an important source of valuable natural biologically active molecules, such as carotenoids, chlorophyll, long-chain polyunsaturated fatty acids, phycobiliproteins, carotenoids and enzymes. Significant advances have been achieved in microalgae biotechnology over the last decade, and the use of microalgae as bioreactors for expressing recombinant proteins is receiving increased interest. Compared with the bioreactor systems that are currently in use, microalgae may be an attractive alternative for the production of pharmaceuticals, recombinant proteins and other valuable products. Products synthesized via the genetic engineering of microalgae include vaccines, antibodies, enzymes, blood-clotting factors, immune regulators, growth factors, hormones, and other valuable products, such as the anticancer agent Taxol. In this paper, we briefly compare the currently used bioreactor systems, summarize the progress in genetic engineering of microalgae, and discuss the potential for microalgae as bioreactors to produce pharmaceuticals.
作为光合生物，微藻能够有效地将太阳能转化为生物质。微藻目前被用作重要的有价值的天然生物活性分子来源，如类胡萝卜素、叶绿素、长链多不饱和脂肪酸、藻胆蛋白、类胡萝卜素和酶。在过去十年中，微藻生物技术取得了重大进展，将微藻用作表达重组蛋白的生物反应器正受到越来越多的关注。与目前使用的生物反应器系统相比，微藻可能是生产药物、重组蛋白和其他有价值产品的有吸引力的替代方案。通过微藻基因工程合成的产品包括疫苗、抗体、酶、凝血因子、免疫调节剂、生长因子、激素以及其他有价值的产品，如抗癌药物紫杉醇。在本文中，我们简要比较了目前使用的生物反应器系统，总结了微藻基因工程的进展，并讨论了微藻作为生物反应器生产药物的潜力。
