Hong Yoo-Seung, Kim Jongseong, Sung Hyuk-Kee
School of Electronic and Electric Engineering, Hongik University, Seoul 121-791, Korea.
Department of Neurology, Molecular Imaging and Neurovascular Research (MINER) Laboratory, Dongguk University Ilsan Hospital, Goyang 10326, Korea.
Sensors (Basel). 2016 Jun 18;16(6):914. doi: 10.3390/s16060914.
We numerically demonstrated the characteristics of a functional hydrogel layer on a silicon-based grating waveguide for a simple, cost-effective refractive index (RI) biochemical sensor. The RI of the functional hydrogel layer changes when a specific biochemical interaction occurs between the hydrogel-linked receptors and injected ligand molecules. The transmission spectral profile of the grating waveguide shifts depends on the amount of RI change caused by the functional layer. Our characterization includes the effective RI change caused by the thickness, functional volume ratio, and functional strength of the hydrogel layer. The results confirm the feasibility of, and set design rules for, hydrogel-assisted silicon-based grating waveguides.
我们通过数值模拟展示了用于简单、经济高效的折射率（RI）生化传感器的硅基光栅波导上功能水凝胶层的特性。当水凝胶连接的受体与注入的配体分子之间发生特定的生化相互作用时，功能水凝胶层的折射率会发生变化。光栅波导的传输光谱轮廓的移动取决于功能层引起的折射率变化量。我们的表征包括由水凝胶层的厚度、功能体积比和功能强度引起的有效折射率变化。结果证实了水凝胶辅助硅基光栅波导的可行性，并制定了设计规则。
