海鞘甾醇C，一种从地中海被囊动物烟色海鞘中分离出的新型二硫酸化甾体。
Phallusiasterol C, A New Disulfated Steroid from the Mediterranean Tunicate Phallusia fumigata.
作者信息
Imperatore Concetta, Senese Maria, Aiello Anna, Luciano Paolo, Fiorucci Stefano, D'Amore Claudio, Carino Adriana, Menna Marialuisa
机构信息
The NeaNat Group, Department of Pharmacy, University of Naples "Federico II", Via D. Montesano 49, Napoli 80131, Italy.
Department of Surgical and Biomedical Sciences, Faculty of Medicine, University of Perugia, Via Gambuli 1, S. Andrea delle Fratte, Perugia 06132, Italy.
出版信息
Mar Drugs. 2016 Jun 18;14(6):117. doi: 10.3390/md14060117.
A new sulfated sterol, phallusiasterol C (1), has been isolated from the Mediterranean ascidian Phallusia fumigata and its structure has been determined on the basis of extensive spectroscopic (mainly 2D NMR) analysis. The possible role in regulating the pregnane X receptor (PXR) activity of phallusiasterol C has been investigated; although the new sterol resulted inactive, this study adds more items to the knowledge of the structure-PXR regulating activity relationships in the case of sulfated steroids.
一种新的硫酸化甾体化合物，烟海鞘甾醇C（1），已从地中海海鞘烟海鞘中分离出来，其结构已通过广泛的光谱分析（主要是二维核磁共振）确定。研究了烟海鞘甾醇C在调节孕烷X受体（PXR）活性方面可能发挥的作用；尽管这种新的甾体化合物没有活性，但这项研究为硫酸化甾体化合物的结构与PXR调节活性关系的知识增添了更多内容。
Zotero 插件