Sung Ping-Jyun, Lin Mei-Ru, Chen Jih-Jung, Lin Shen-Fan, Wu Yang-Chang, Hwang Tsong-Long, Fang Lee-Shing
National Museum of Marine Biology and Aquarium, Pingtung, Taiwan, R.O.C.
Chem Pharm Bull (Tokyo). 2007 Apr;55(4):666-8. doi: 10.1248/cpb.55.666.
Two 27C hydroperoxysterols, 7beta-hydroperoxycholesterol (1) and its stereoisomer 7alpha-hydroperoxycholesterol (2), were isolated from the lipophilic extracts of a Formosan tunicate belonging to the genus Eudistoma. The structures of sterols 1 and 2 were elucidated on the basis of extensive spectral data analyses. Cytotoxicity of sterols 1 and 2 against a limited panel of cancer cell lines is also described. Sterol 1 show weak inhibitory effects on human neutrophil elastase release.
从属于Eudistoma属的一种台湾被囊动物的亲脂性提取物中分离出两种27C氢过氧甾醇，7β-氢过氧胆固醇（1）及其立体异构体7α-氢过氧胆固醇（2）。基于广泛的光谱数据分析阐明了甾醇1和2的结构。还描述了甾醇1和2对一组有限的癌细胞系的细胞毒性。甾醇1对人中性粒细胞弹性蛋白酶释放显示出微弱的抑制作用。
