Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
Department of Microbiology, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
Mar Drugs. 2011;9(10):1829-1839. doi: 10.3390/md9101829. Epub 2011 Oct 10.
In previous studies on the secondary metabolites of the Taiwanese octocoral Isis hippuris, specimens have always been collected at Green Island. In the course of our studies on bioactive compounds from marine organisms, the acetone-solubles of the Taiwanese octocoral I. hippuris collected at Orchid Island have led to the isolation of five new polyoxygenated steroids: hipposterone M-O (1-3), hipposterol G (4) and hippuristeroketal A (5). The structures of these compounds were determined on the basis of their spectroscopic and physical data. The anti-HCMV (human cytomegalovirus) activity of 1-5 and their cytotoxicity against selected cell lines were evaluated. Compound 2 exhibited inhibitory activity against HCMV, with an EC(50) value of 6.0 μg/mL.
在先前对台湾柳珊瑚次级代谢产物的研究中，标本一直是在绿岛采集的。在我们对海洋生物活性化合物的研究过程中，从兰屿采集的台湾柳珊瑚 I. hippuris 的丙酮可溶部分导致了五个新的多氧化甾体的分离：hipposterone M-O（1-3）、hipposterol G（4）和 hippuristeroketal A（5）。这些化合物的结构是根据它们的光谱和物理数据确定的。评估了 1-5 对 HCMV（人巨细胞病毒）的活性及其对选定细胞系的细胞毒性。化合物 2 对 HCMV 表现出抑制活性，EC（50）值为 6.0 μg/mL。
