Colacci Michael, Murthy Karna, DeRegnier Raye-Ann O, Khan Janine Y, Robinson Daniel T
Division of Neonatology, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Am J Perinatol. 2017 Jan;34(2):130-137. doi: 10.1055/s-0036-1584520. Epub 2016 Jun 20.
To estimate associations of exclusive human milk (EHM) feedings with growth and neurodevelopment through 18 months corrected age (CA) in extremely low birth weight (ELBW) infants. ELBW infants admitted from July 2011 to June 2013 who survived were reviewed. Infants managed from July 2011 to June 2012 were fed with bovine milk-based fortifiers and formula (BOV). Beginning in July 2012, initial feedings used a human milk-based fortifier to provide EHM feedings. Infants were grouped on the basis of feeding regimen. Primary outcomes were the Bayley-III cognitive scores at 6, 12, and 18 months and growth. Infants ( = 85; 46% received EHM) were born at 26 ± 1.9 weeks ( = 0.92 between groups) weighing 776 ± 139 g ( = 0.67 between groups). Cognitive domain scores were similar at 6 months (BOV: 96 ± 7; EHM: 95 ± 14; = 0.70), 12 months (BOV: 97 ± 10; EHM: 98 ± 9; = 0.86), and 18 months (BOV: 97 ± 16; EHM: 98 ± 14; = 0.71) CA. Growth velocity prior to discharge (BOV: 12.1 ± 5.2 g/kg/day; EHM: 13.1 ± 4.0 g/kg/day; = 0.33) and subsequent growth was similar between groups. EHM feedings appear to support similar growth and neurodevelopment in ELBW infants as compared with feedings containing primarily bovine milk-based products.
评估极低出生体重（ELBW）婴儿纯母乳喂养（EHM）至矫正年龄18个月时与生长及神经发育的相关性。回顾2011年7月至2013年6月期间存活的ELBW入院婴儿。2011年7月至2012年6月管理的婴儿采用基于牛乳的强化剂和配方奶（BOV）喂养。从2012年7月开始，初始喂养使用基于人乳的强化剂以提供EHM喂养。婴儿根据喂养方案分组。主要结局为6个月、12个月和18个月时的贝利婴幼儿发展量表第三版（Bayley-III）认知评分及生长情况。85名婴儿（46%接受EHM喂养）出生时孕周为26±1.9周（组间P=0.92），体重776±139g（组间P=0.67）。6个月时（BOV：96±7；EHM：95±14；P=0.70）、12个月时（BOV：97±10；EHM：98±9；P=0.86）和18个月时（BOV：97±16；EHM：98±14；P=0.71）矫正年龄时的认知领域评分相似。出院前的生长速度（BOV：12.1±5.2g/kg/天；EHM：13.1±4.0g/kg/天；P=0.33）及随后的生长在两组间相似。与主要含牛乳产品的喂养相比，EHM喂养似乎能使ELBW婴儿获得相似的生长及神经发育。
