Sui Z Y, Li J, Cheng G L, Wang S F
Department of Gastroenterology, The Second Affiliate Hospital of Soochow University, Suzhou, China.
Genet Mol Res. 2016 May 13;15(2):gmr7661. doi: 10.4238/gmr.15027661.
Hepatocellular carcinoma (HCC) is a complex polygenic disease whose development is dependent on many genetic factors. The let-7 family, an important and widely studied microRNA family, has been shown to play an important role in the initiation and progression of HCC. In this study, we examined the possible associations between single-nucleotide polymorphisms in the promoter region of the let-7 family (rs10877887) and the susceptibility and prognosis of HCC, using a case-control research model. Eighty-nine HCC patients and 95 healthy controls were genotypes by direct sequencing, and the correlation between rs10877887 genotypes and HCC susceptibility was evaluated using an unconditional logistic regression model. Populations with the CT + CC genotype were at a significantly higher risk of HCC compared to those with the TT genotype (CT + CC vs TT: odds ratio = 3.52, 95% confidence interval = 1.90-6.52; P < 0.05). Furthermore, we discovered that the genetic variant of rs10877887 might serve as a prognostic marker for survival in HCC patients, as the CT + CC genotype was associated with poor prognosis.
肝细胞癌（HCC）是一种复杂的多基因疾病，其发展取决于许多遗传因素。let-7家族是一个重要且被广泛研究的微小RNA家族，已被证明在HCC的发生和发展中起重要作用。在本研究中，我们使用病例对照研究模型，研究了let-7家族启动子区域单核苷酸多态性（rs10877887）与HCC易感性和预后之间的可能关联。通过直接测序对89例HCC患者和95例健康对照进行基因分型，并使用无条件逻辑回归模型评估rs10877887基因型与HCC易感性之间的相关性。与TT基因型相比，CT + CC基因型人群患HCC的风险显著更高（CT + CC与TT：比值比 = 3.52，95%置信区间 = 1.90 - 6.52；P < 0.05）。此外，我们发现rs10877887的基因变异可能作为HCC患者生存的预后标志物，因为CT + CC基因型与预后不良相关。
