Thomas P, Said J W, Rosenfelt F P, Heifetz L J
Am J Clin Pathol. 1984 Feb;81(2):243-8. doi: 10.1093/ajcp/81.2.243.
Immunologic studies demonstrate that non-Hodgkin's lymphomas are derived predominantly from B- or T-lymphoid cells, while node-based tumors of true histiocytic derivation are rare, with few documented cases. This report describes the clinical, histologic, immunohistochemical, and ultrastructural features of two cases of node-based true histiocytic lymphoma. Distinctive ultrastructural features included numerous cytoplasmic lysosomes, surface microvillous processes, and occasional cell junctions, and the cells stained strongly for alpha-napthyl acetate esterase and alpha one-antitrypsin. Since there are few specific histologic features, special technics may be essential in confirming the diagnosis of true histiocytic lymphoma, and determining appropriate therapy.
免疫学研究表明，非霍奇金淋巴瘤主要起源于B淋巴细胞或T淋巴细胞，而真正组织细胞来源的淋巴结肿瘤则很罕见，仅有少数病例记载。本报告描述了两例淋巴结型真正组织细胞淋巴瘤的临床、组织学、免疫组化及超微结构特征。独特的超微结构特征包括大量胞质溶酶体、表面微绒毛突起及偶尔的细胞连接，且细胞对α-萘乙酸酯酶和α1-抗胰蛋白酶染色呈强阳性。由于特异性组织学特征较少，特殊技术对于确诊真正组织细胞淋巴瘤及确定合适的治疗方法可能至关重要。
