Chhetry Manisha, Thakur Achala, Uprety Dhruba Kumar, Basnet Pritha, Joshi Rakshya
J Ayub Med Coll Abbottabad. 2016 Jan-Mar;28(1):18-21.
Hyperemesis gravidarum (HG) is the most severe form of nausea and vomiting of pregnancy which can have potentially dangerous complications if untreated. Its treatment is basically supportive as the condition itself is self-limiting. The aim of our study was to evaluate maternal characteristics in patients with HG including risk factors and treatment outcome with respect to improvement in Pregnancy Unique Quantification of Emesis (PUQE) scores, number of doses of antiemetics used, weight gain during treatment and duration of intravenous fluid therapy
A cross-sectional study where all women admitted to B.P. Koirala Institute of Health Sciences with a diagnosis of HG during a period of one year were studied for different maternal characteristics. The severity of disease was quantified using Modified PUQE score and the various treatment outcomes considered.
The admission for hyperemesis gravidarum (n=81, including 13 readmissions) was 10.64% of total early pregnancy admissions (n = 735).The condition was more common in nulliparous patients (56%) at a mean period of gestation of 8.93 ± 2.33 wks. Most patients suffered from moderate to severe disease at presentation, mean PUQE scores being 12.29 ± 1.59. The median number of doses of intravenous antiemetics used was three (IQR 3-6), median weight gain was one kg (IQR 0-1 kg), median duration of intravenous fluid therapy was 24 hrs (IQR 24-48 hrs) and mean length of hospital stay was 3.2 ± 1.48 days.
Hyperemesis is one of the common causes of hospitalization in early pregnancy. Treatment has favourable outcome with early recovery.
妊娠剧吐（HG）是妊娠期恶心和呕吐最严重的形式，如果不治疗可能会引发潜在的危险并发症。由于该病症本身具有自限性，其治疗基本上是支持性的。我们研究的目的是评估妊娠剧吐患者的母体特征，包括危险因素以及与妊娠呕吐独特量化（PUQE）评分改善、使用的止吐药剂量、治疗期间体重增加和静脉输液治疗持续时间相关的治疗结果。
一项横断面研究，对在一年期间因诊断为妊娠剧吐而入住B.P. Koirala健康科学研究所的所有女性的不同母体特征进行研究。使用改良的PUQE评分对疾病严重程度进行量化，并考虑各种治疗结果。
妊娠剧吐的入院人数（n = 81，包括13例再次入院）占早期妊娠入院总数（n = 735）的10.64%。该病症在初产妇中更为常见（56%），平均妊娠期为8.93±2.33周。大多数患者就诊时患有中度至重度疾病，平均PUQE评分为12.29±1.59。静脉使用止吐药的中位数剂量为3剂（四分位间距3 - 6），体重增加中位数为1千克（四分位间距0 - 1千克），静脉输液治疗的中位数持续时间为24小时（四分位间距24 - 48小时），平均住院时间为3.2±1.48天。
妊娠剧吐是早期妊娠住院的常见原因之一。治疗效果良好，患者恢复较早。
