新型含异噁唑基吡唑肟衍生物的设计、合成与生物活性。

Design, Synthesis and Bioactivities of Novel Isoxazole-Containing Pyrazole Oxime Derivatives.

机构信息

College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019, China.

School of Environmental and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang 212003, China.

出版信息

Molecules. 2017 Nov 27;22(12):2000. doi: 10.3390/molecules22122000.

DOI:10.3390/molecules22122000

PMID:29186906

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6149770/

Abstract

In this study, in order to find novel biologically active pyrazole oxime derivatives, twenty-eight new pyrazole oxime compounds containing a substituted isoxazole ring were synthesized and evaluated for their acaricidaland insecticidal activities. Bioassays exhibited that some target compounds indicated good acaricidal and insecticidal activities against , , , and . Especially, compounds , , , and showed 100.00%, 90.56%, 90.78%, and 90.62% insecticidal activities against at the concentration of 20 μg/mL, respectively, compounds and had 70.86% and 100.00% insecticidal activities against at 20 μg/mL, respectively.

摘要

在这项研究中，为了寻找新型具有生物活性的吡唑肟衍生物，合成了 28 种新型含取代异恶唑环的吡唑肟化合物，并对其杀螨和杀虫活性进行了评价。生物测定结果表明，部分目标化合物对、、、表现出良好的杀螨和杀虫活性。特别是化合物、、、对浓度为 20μg/mL 时的杀虫活性分别为 100.00%、90.56%、90.78%和 90.62%，化合物和对 20μg/mL 时的杀虫活性分别为 70.86%和 100.00%。