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与自然妊娠相比,辅助生殖技术后双绒毛膜双胎妊娠的产科及围产期结局

Obstetrics and perinatal outcomes of dichorionic twin pregnancy following ART compared with spontaneous pregnancy.

作者信息

Pourali Leila, Ayati Sedigheh, Jelodar Shahrzad, Zarifian Ahmadreza, Sheikh Andalibi Mohammad Sobhan

机构信息

Department of Obstetrics and Gynecology, Women's Health Research Center, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

出版信息

Int J Reprod Biomed. 2016 May;14(5):317-22.

Abstract

INTRODUCTION

Regarding to the recent advances in assisted reproductive techniques (ART), twin and multiple pregnancies have increased during past years.

OBJECTIVE

This study was performed to compare obstetrics and perinatal outcomes of dichorionic twin pregnancy following ART with spontaneous pregnancy.

MATERIALS AND METHODS

In this cross-sectional study which was performed in Ghaem Hospital, Mashhad University of Medical Sciences, 107 dichorionic twin pregnancy were enrolled in two groups: spontaneous group (n=96) and ART group (n=31). Basic criteria and obstetrics and neonatal outcomes information including demographic data, gestational age, mode of delivery, pregnancy complications (preeclampsia, gestational diabetes, preterm labor, and intrauterine growth retardation (IUGR), postpartum hemorrhage), neonatal outcomes (weight, first and fifth minute Apgar score, Neonatal Intensive Care Unit (NICU) admission, mortality, respiratory distress, and icterus) were recorded using a questionnaire.

RESULTS

Preterm labor, gestational diabetes, and preeclampsia were significantly higher in ART group compared to spontaneous pregnancy group. However, other factors such as anemia, IUGR, postpartum hemorrhage, and intrauterine fetal death (IUFD) were not significantly different between groups. There were no significant differences between groups in terms of neonatal outcomes (weight, 1(st) and 5(th) min Apgar score <7, NICU hospitalization, mortality, respiratory distress, and icterus).

CONCLUSION

With regard of significantly higher poor outcomes such as preeclampsia, gestational diabetes and preterm labor in ART group, the couples should be aware of these potential risks before choosing ART.

摘要

引言

随着辅助生殖技术(ART)的最新进展,过去几年中双胎及多胎妊娠有所增加。

目的

本研究旨在比较ART后双绒毛膜双胎妊娠与自然妊娠的产科及围产期结局。

材料与方法

在马什哈德医科大学加姆医院进行的这项横断面研究中,107例双绒毛膜双胎妊娠被分为两组:自然妊娠组(n = 96)和ART组(n = 31)。使用问卷记录基本标准以及产科和新生儿结局信息,包括人口统计学数据、孕周、分娩方式、妊娠并发症(子痫前期、妊娠期糖尿病、早产和胎儿生长受限(IUGR)、产后出血)、新生儿结局(体重、第1分钟和第5分钟阿氏评分、新生儿重症监护病房(NICU)入院、死亡率、呼吸窘迫和黄疸)。

结果

与自然妊娠组相比,ART组的早产、妊娠期糖尿病和子痫前期显著更高。然而,两组之间的其他因素如贫血、IUGR、产后出血和胎儿宫内死亡(IUFD)并无显著差异。两组在新生儿结局(体重、第1分钟和第5分钟阿氏评分<7、NICU住院、死亡率、呼吸窘迫和黄疸)方面无显著差异.

结论

鉴于ART组中子痫前期、妊娠期糖尿病和早产等不良结局显著更高,夫妇在选择ART之前应了解这些潜在风险。

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