Van Campen H, Easterday B C, Hinshaw V S
Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison 53706.
J Gen Virol. 1989 Feb;70 ( Pt 2):467-72. doi: 10.1099/0022-1317-70-2-467.
Infection of chickens by a virulent avian influenza A virus, A/turkey/Ont/7732/66 (H5N9), was associated with a severe lymphopenia. High titres of infectious virus were found in lymphoid tissues early in infection and were accompanied by severe damage to the lymphocyte populations as demonstrated by histopathological examination. Non-lymphoid cell populations in these tissues were unaffected, as were other organs examined. The viral nucleoprotein was localized by immunoperoxidase staining to lymphocytes in affected tissues early in infection.
高致病性甲型禽流感病毒A/火鸡/安大略/7732/66（H5N9）感染鸡后会导致严重的淋巴细胞减少。感染初期在淋巴组织中发现了高滴度的传染性病毒，并且组织病理学检查表明淋巴细胞群体受到了严重损伤。这些组织中的非淋巴细胞群体未受影响，其他检查的器官也是如此。在感染初期，通过免疫过氧化物酶染色在受影响组织的淋巴细胞中检测到病毒核蛋白。
