Zheng Fang, Roisman Luiz, Schaal Karen B, Miller Andrew R, Robbins Gillian, Gregori Giovanni, Rosenfeld Philip J
Ophthalmic Surg Lasers Imaging Retina. 2016 Jun 1;47(6):517-22. doi: 10.3928/23258160-20160601-02.
To demonstrate possible flow artifacts when imaging drusen with optical coherence tomography angiography (OCTA).
Patients with drusen were enrolled in a prospective OCT study using the Zeiss AngioPlex OCTA instrument (Carl Zeiss Meditec, Dublin, CA). Two kinds of en face slabs were created for visualizing both structure and flow. The first slab followed the contour of Bruch's membrane. The second slab had an inner boundary following the retinal pigment epithelium (RPE) contour and an outer boundary following the contour of Bruch's membrane. The structure and flow signals from within the drusen were compared.
Eleven eyes of nine patients with age-related macular degeneration and drusen were imaged. In all 11 eyes, an artifactual flow signal was seen on the first slab where it intersected the RPE. This flow signal was a projection artifact from the overlying retinal vessels. The second slab did not show evidence of flow within drusen.
OCTA decorrelation projection artifacts can be misinterpreted as apparent flow within drusen if the slab region includes hyperreflective boundary layers such as the RPE. [Ophthalmic Surg Lasers Imaging Retina. 2016;47:517-522.].
利用光学相干断层扫描血管造影（OCTA）成像检测玻璃膜疣时，证明可能出现的血流伪像。
招募患有玻璃膜疣的患者参与一项前瞻性OCT研究，使用蔡司AngioPlex OCTA仪器（卡尔蔡司医疗技术公司，加利福尼亚州都柏林）。创建了两种正面平板图像用于观察结构和血流。第一种平板图像沿着布鲁赫膜的轮廓。第二种平板图像的内边界沿着视网膜色素上皮（RPE）轮廓，外边界沿着布鲁赫膜的轮廓。比较玻璃膜疣内部的结构和血流信号。
对9例年龄相关性黄斑变性伴玻璃膜疣患者的11只眼睛进行了成像。在所有11只眼睛中，在第一种平板图像与RPE相交处可见人为血流信号。这种血流信号是来自上方视网膜血管的投影伪像。第二种平板图像未显示玻璃膜疣内部有血流迹象。
如果平板图像区域包括高反射边界层（如RPE），OCTA去相关投影伪像可能会被误判为玻璃膜疣内的明显血流。[《眼科手术、激光与视网膜成像》。2016；47：517 - 522。]
