Louzada Ricardo N, de Carlo Talisa E, Adhi Mehreen, Novais Eduardo A, Durbin Mary K, Cole Emily, Lane Mark, Moghimi Omid, Arya Malvika, Filho Marco Bonini, Witkin Andre J, Baumal Caroline R, Ávila Marcos, Duker Jay S, Waheed Nadia K
New England Eye Center and Tufts Medical Center, Tufts University, Boston, Massachusetts; Federal University of Goiás, Goiás, Brazil.
New England Eye Center and Tufts Medical Center, Tufts University, Boston, Massachusetts; Department of Electrical Engineering and Computer Science, and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts.
Can J Ophthalmol. 2017 Aug;52(4):419-424. doi: 10.1016/j.jcjo.2016.12.012. Epub 2017 Mar 15.
To describe optical coherence tomography angiography (OCTA) reflectance artifacts secondary to retinal pigment epithelial detachment (RPED).
Retrospective review.
Four eyes from 4 subjects were included. Three presented with RPED and 1 eye was a normal control. Two eyes diagnosed with RPED and the normal eye were evaluated using en face OCTA centred at the fovea acquired using the RTVue XR Avanti (Optovue Inc). In the third eye with RPED, OCTA imaging was performed using a CIRRUS 5000 prototype modified to do OCTA imaging on a spectral domain OCT platform provided by Carl Zeiss Meditec, Inc. The segmented OCTA angiograms were overlaid to determine if the flow patterns seen at the edge of the RPEDs were due to reflectance from the inner retinal vessels, also known as "decorrelation tails."
OCTA projection artifacts were noted when segmentation lines intersected with the boundary of the RPED. The overlaid segmented OCTA from the 3 RPED eyes imaged using each system revealed the same vasculature pattern at the edges of the RPED as that of the inner retina, demonstrating the "decorrelation tails" artifact, which caused the RPED to appear as a bright ring on the segmented OCTA.
OCTA images are susceptible to various known artifacts. This series describes the impact of the projection artifact seen at the edges of an RPED that simulates appearance of flow but is actually due to reflectance of the inner retinal vasculature on the RPED.
描述视网膜色素上皮脱离（RPED）继发的光学相干断层扫描血管造影（OCTA）反射伪影。
回顾性研究。
纳入4名受试者的4只眼。3只眼出现RPED，1只眼作为正常对照。对2只诊断为RPED的眼和正常眼使用以黄斑为中心的视网膜正面OCTA进行评估，该检查使用RTVue XR Avanti（Optovue公司）获得。在第3只患有RPED的眼中，使用经改装的CIRRUS 5000原型机进行OCTA成像，该原型机可在卡尔·蔡司医疗技术公司提供的光谱域OCT平台上进行OCTA成像。将分割后的OCTA血管造影图叠加，以确定在RPED边缘看到的血流模式是否是由于视网膜内血管的反射所致，即所谓的“去相关尾”。
当分割线与RPED边界相交时，可观察到OCTA投影伪影。使用每个系统对3只患有RPED的眼进行成像并叠加分割后的OCTA，结果显示RPED边缘的血管结构与视网膜内层相同，证实了“去相关尾”伪影，该伪影导致RPED在分割后的OCTA上呈现为亮环。
OCTA图像易受各种已知伪影的影响。本系列研究描述了在RPED边缘看到的投影伪影的影响，该伪影模拟了血流外观，但实际上是由于视网膜内血管在RPED上的反射所致。
