State Key Joint Laboratory of Environmental Simulation and Pollution Control, School of Environment, Tsinghua University, Beijing 100084, China.
State Key Joint Laboratory of Environmental Simulation and Pollution Control, School of Environment, Tsinghua University, Beijing 100084, China.
Sci Total Environ. 2016 Nov 1;569-570:23-30. doi: 10.1016/j.scitotenv.2016.06.113. Epub 2016 Jun 18.
An investigation to study the distribution and persistence of cephalosporins in the cephalosporin producing wastewater was carried out in this paper. The target cephalosporins included ceftriaxone (CRO), cefalexin (CEF), cefotaxime (CTX), cefazolin (CZO), cefuroxime (CXM), cefoxitin (CFX) and cefradine (CF). A rapid and reliable detection method for cephalosporins was established based on solid phase extraction and ultra-performance liquid chromatography - tandem mass spectrometry. In the cephalosporin producing wastewater effluent (CPWWeff), the limit of quantification for the targets ranged from 27.5ng/L to 131.8ng/L, and the recoveries for all of the analytes ranged from 73% to 102%. The mean concentrations of the seven cephalosporins were 12.85-141.55μg/L and 0.05-24.38μg/L in cephalosporin producing wastewater influent and effluent, respectively. Although high removal efficiencies were achieved for the cephalosporins (78.8-99.7%), up to 1.9kg of cephalosporins was discharged per day from the investigated C-WWTP. The degradation processes of CRO, CEF, CZO and CXM followed first-order kinetics in CPWWeff under all of the testing conditions. The degradation rates of tested cephalosporins were accelerated by high temperature and light. Persistence of CXM was the highest among the four tested cephalosporins in CPWWeff.
本文对头孢菌素生产废水中头孢菌素的分布和持久性进行了研究。目标头孢菌素包括头孢曲松（CRO）、头孢氨苄（CEF）、头孢噻肟（CTX）、头孢唑林（CZO）、头孢呋辛（CXM）、头孢西丁（CFX）和头孢拉定（CF）。本文基于固相萃取和超高效液相色谱-串联质谱法建立了一种快速可靠的头孢菌素检测方法。在头孢菌素生产废水（CPWWeff）中，目标物的定量限范围为 27.5ng/L 至 131.8ng/L，所有分析物的回收率范围为 73%至 102%。头孢菌素生产废水进水和出水的七种头孢菌素的平均浓度分别为 12.85-141.55μg/L 和 0.05-24.38μg/L。尽管头孢菌素的去除效率很高（78.8-99.7%），但从调查的 C-WWTP 每天仍有 1.9 公斤的头孢菌素被排放。在所有测试条件下，CPWWeff 中的 CRO、CEF、CZO 和 CXM 的降解过程均遵循一级动力学。在高温和光照下，测试的头孢菌素的降解速率加快。在 CPWWeff 中，CXM 的持久性在四种测试头孢菌素中最高。
