Hildebrandt D, Ziegler K, Wollina U
Department of Dermatology, Friedrich-Schiller-University of Jena, Jena, Germany.
Skin Res Technol. 1998 Aug;4(3):130-4. doi: 10.1111/j.1600-0846.1998.tb00097.x.
BACKGROUND/AIMS: The skin barrier function is a multidimensional quality, which can be defined by a combination of noninvasive measurements, including EIectrical impedance (EI) and transepidermal water loss (TEWL).
TEWL and EI were determined on in five different areas of the body in 25 healthy volunteers. The effects of hydration (a 15 min water bath, a 1 h occlusion and application of an oil-in-water emulsion combined with occlusion) were measured on the volar forearm.
EI was highest in the axillary region, followed by the cheek, spinal region, presternal area and upper arm. TEWL was highest in the axillary region, followed by the cheek. Lowest levels were detected in the spinal region, the presternal region and the upper arm. The water bath increased EI but not TEWL. After 1 h occlusion TEWL was not increased and EI decreased, which corresponds to stratum corneum hydration. After a single application of an oil-in-water emulsion, we observed a reduction of EI and an increase of TEWL. The simultaneous use of occlusion and application of an emulsion led to the most significant reduction of EI. TEWL was increased during the following 30 min.
EI and TEWL show a topological variability. Acute hydration increased EI but occlusion and/or moisturizing decreased EI. Acute hydration and occlusion alone did not significantly affect TEWL, but moisturizing in combination caused a longer lasting TEWL increase. To examine the stratum corneum function, the use of different noninvasive techniques seem to provide more complex information.
背景/目的：皮肤屏障功能是一个多维度的特性，可通过包括电阻抗（EI）和经表皮水分流失（TEWL）在内的非侵入性测量组合来定义。
对25名健康志愿者身体的五个不同部位测定TEWL和EI。在掌侧前臂测量水合作用（15分钟水浴、1小时封闭以及应用水包油乳液并结合封闭）的效果。
EI在腋窝区域最高，其次是脸颊、脊柱区域、胸骨前区域和上臂。TEWL在腋窝区域最高，其次是脸颊。在脊柱区域、胸骨前区域和上臂检测到的水平最低。水浴增加了EI但未增加TEWL。封闭1小时后，TEWL未增加且EI降低，这与角质层水合作用一致。单次应用水包油乳液后，我们观察到EI降低且TEWL增加。同时使用封闭和乳液应用导致EI最显著降低。在接下来的30分钟内TEWL增加。
EI和TEWL表现出拓扑变异性。急性水合作用增加EI，但封闭和/或保湿降低EI。单独的急性水合作用和封闭对TEWL没有显著影响，但保湿联合使用会导致TEWL持续更长时间增加。为了检查角质层功能，使用不同的非侵入性技术似乎能提供更复杂的信息。
