Wollina Uwe
Krankenhaus Dresden-Friedrichstadt, Städtisches Klinikum, Akademisches Lehrkrankenhaus der TU Dresden.
GMS Curr Top Otorhinolaryngol Head Neck Surg. 2005;4:Doc17. Epub 2005 Sep 28.
Skin exerts a number of essential protective functions ensuring homeostasis of the whole body. In the present review barrier function of skin and its expression of antimicrobial peptides are discussed. Barrier function is provided by the dynamic stratum corneum structure composed of lipids and corneocytes. Stratum corneum is a conditio sine qua non for terrestrial life. Impairment of barrier function can be due to injury and inflammatory skin diseases. Therapeutic options are discussed with special emphasis of radiodermatitis and irritant contact dermatitis in patients with hearing device. The use of antimicrobial peptides is illustrated by facial inflammatory skin diseases. In wound healing new developments include biotechnological developments of matrix- and growth factors and tissue-engineered skin substitutes. In everyday wound care of chronic wounds the concept of wound bed preparation (TIME) constitutes the base of successful treatment.
皮肤发挥着许多重要的保护功能，确保全身的稳态。在本综述中，讨论了皮肤的屏障功能及其抗菌肽的表达。屏障功能由由脂质和角质形成细胞组成的动态角质层结构提供。角质层是陆地生命必不可少的条件。屏障功能受损可能是由于损伤和炎症性皮肤病。讨论了治疗选择，特别强调了听力装置患者的放射性皮炎和刺激性接触性皮炎。面部炎症性皮肤病说明了抗菌肽的使用。在伤口愈合方面，新进展包括基质和生长因子的生物技术开发以及组织工程皮肤替代品。在慢性伤口的日常护理中，伤口床准备（TIME）的概念是成功治疗的基础。
