Fluhr J W, Lazzerini S, Distante F, Gloor M, Berardesca E
Department of Dermatology, Städtisches Klinikum Karlsruhe, Germany.
Skin Pharmacol Appl Skin Physiol. 1999 Jul-Aug;12(4):193-8. doi: 10.1159/000066243.
We aimed to evaluate whether prolonged occlusion can induce stratum corneum barrier damage, alterations in stratum corneum hydration or water-holding capacity (WHC) lasting longer than the occlusion time.
12 subjects were occluded on the forearm for 24, 48, 72 and 96 h. Two hours after occlusion removal, transepidermal water loss (TEWL) and skin hydration were measured and a sorption-desorption test performed.
TEWL showed an increase reaching a plateau on day 2. Hydration and WHC did not show significant changes. Hygroscopicity showed the highest level on day 1, decreasing during the following days. A highly significant correlation between capacitance values and the WHC could be detected (p < 0.0001, r = 0.8206). No correlation could be detected between hygroscopicity and TEWL.
Prolonged occlusion induces barrier damage without skin dryness. Occlusion also induces an increased hygroscopicity. A correlation between these two findings could not be proven.
我们旨在评估长时间封闭是否会导致角质层屏障受损、角质层水合作用或持水能力（WHC）的改变，且这种改变持续时间是否长于封闭时间。
12名受试者的前臂被封闭24、48、72和96小时。去除封闭后两小时，测量经表皮水分流失（TEWL）和皮肤水合作用，并进行吸附-解吸试验。
TEWL在第2天出现增加并达到平稳状态。水合作用和WHC未显示出显著变化。吸湿性在第1天达到最高水平，在随后几天下降。电容值与WHC之间存在高度显著的相关性（p < 0.0001，r = 0.8206）。吸湿性与TEWL之间未检测到相关性。
长时间封闭会导致屏障受损但不会引起皮肤干燥。封闭还会导致吸湿性增加。这两个发现之间的相关性尚未得到证实。
