Bilotta Federico, Qeva Ega, Matot Idit
a Department of Anesthesiology, Critical Care and Pain Medicine , 'Sapienza' University of Rome , Rome , Italy.
b Department of Anesthesiology, Intensive Care and Pain Medicine , Tel Aviv Medical Center , Tel Aviv , Israel.
Expert Rev Neurother. 2016 Nov;16(11):1311-1320. doi: 10.1080/14737175.2016.1203256. Epub 2016 Jul 11.
Preclinical and clinical evidence suggest an association between anesthesia and cognitive disorders ranging from postoperative chronic dysfunction to Alzheimer's disease. Recent clinical insights are summarized in this paper. Areas covered: This systematic review was conducted and written in accordance with the preferred reporting items for systematic reviews and meta-analyses statement and was registered in the International Prospective Register of Systematic Review database. A literature search of PubMed, EMBASE and SCOPUS was accomplished according to a written protocol that included: clinical trials on humans, articles in English, papers published between April 2010 and February 2016 and complete studies. Expert commentary: There is a growing interest in establishing the possible relationship between anesthesia and the onset and progression of cognitive disorders. Further studies are required to determine the methods of monitoring anesthesia in older adults with dementia undergoing surgical procedures.
临床前和临床证据表明，麻醉与从术后慢性功能障碍到阿尔茨海默病等认知障碍之间存在关联。本文总结了近期的临床见解。涵盖领域：本系统评价按照系统评价与Meta分析的首选报告项目声明进行撰写，并在国际前瞻性系统评价注册数据库中进行了注册。根据书面方案，对PubMed、EMBASE和SCOPUS进行了文献检索，该方案包括：针对人类的临床试验、英文文章、2010年4月至2016年2月发表的论文以及完整的研究。专家评论：人们越来越关注确定麻醉与认知障碍的发生和进展之间的可能关系。需要进一步研究以确定对接受外科手术的老年痴呆患者进行麻醉监测的方法。
