Dos Santos Gramma Luciane Souza, Marques Franciane Martins, Vittorazzi Cátia, de Andrade Thiago Antônio Moretti, Frade Marco Andrey Cipriani, de Andrade Tadeu Uggere, Endringer Denise Coutinho, Scherer Rodrigo, Fronza Marcio
Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Vila Velha, Vila Velha, Espirito Santo, Brazil.
Programa de Pós-graduação em Ciências Biomédicas, Centro Universitário Hermínio Ometto - UNIARARAS, Araras, Sao Paulo, Brazil.
J Ethnopharmacol. 2016 Aug 22;190:319-27. doi: 10.1016/j.jep.2016.06.050. Epub 2016 Jun 18.
Struthanthus vulgaris (Vell.) Mart. (Loranthaceae) has been largely used in traditional folk medicine in Brazil as an anti-inflammatory agent and to treat various skin disorders, including wounds.
To investigated the influence of 5% Struthanthus vulgaris ointment during cutaneous wound healing in rats.
Twenty Wistar rats were used in each group according the daily treatment, S. vulgaris 5% ointment (SV 5%) and vehicle control groups. Four full thicknesses wounds were punched in back side skin of each animal, and five animals were sacrificed after 2, 7, 14 and 21 days after surgery for histological, immunological and biochemical analysis.
A significant wound closured area in the S. vulgaris 5% group of about 38% and 35% as compared to 19% and 21% in the control group was observed after 2 and 5 days, respectively. Histological and biochemical analysis of the skin biopsies showed that S. vulgaris treated wounds exhibited increased granulation tissue and regulated the inflammatory response by modulating the release of pro and anti-inflammatory cytokines like IL-1α, TNF-α and IL-10, nitric oxide and, growth factors like TGF-β. Moreover, S. vulgaris showed a marked and robust increase in the deposition and organization of collagen fibers in the wounds, and improve the quality of the scar tissue.
Altogether these data revealed that S. vulgaris seems to prevent an over expression of inflammation and accelerates wound epithelialization and might be beneficial for treating healing disorders.
普通寄生花（Struthanthus vulgaris (Vell.) Mart.，桑寄生科）在巴西传统民间医学中被广泛用作抗炎剂，用于治疗各种皮肤疾病，包括伤口。
研究5%普通寄生花软膏对大鼠皮肤伤口愈合的影响。
根据每日治疗分组，每组使用20只Wistar大鼠，分为5%普通寄生花软膏组（SV 5%）和赋形剂对照组。在每只动物的背部皮肤打四个全层伤口，术后2、7、14和21天分别处死5只动物，进行组织学、免疫学和生化分析。
与对照组术后2天和5天分别为19%和21%相比，5%普通寄生花软膏组伤口闭合面积显著增加，分别约为38%和35%。皮肤活检的组织学和生化分析表明，普通寄生花治疗的伤口肉芽组织增多，通过调节促炎和抗炎细胞因子如IL-1α、TNF-α和IL-10、一氧化氮以及生长因子如TGF-β的释放来调节炎症反应。此外，普通寄生花使伤口中胶原纤维的沉积和排列显著增强，并改善了瘢痕组织的质量。
这些数据表明，普通寄生花似乎可防止炎症过度表达，加速伤口上皮化，可能有益于治疗愈合障碍。
