Zhang Kai, Wong Jon W, Krynitsky Alexander J, Trucksess Mary W
U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Regulatory Science, 5100 Paint Branch Pkwy, College Park, MD 20740.
J AOAC Int. 2016 Jul;99(4):890-894. doi: 10.5740/jaoacint.16-0116. Epub 2016 Jun 21.
The presence of mycotoxins (such as aflatoxins, deoxynivalenol, fumonisins, and patulin) is routinely monitored by the U.S. Food and Drug Administration (FDA) to ensure that their concentrations in food are below the levels requiring regulatory action or advisories. To improve the efficiency of mycotoxin analysis, the researchers at the FDA's Center for Food Safety and Applied Nutrition have been evaluating modern LC-MS technologies. Consequently, a variety of LC-tandem MS and LC-high-resolution MS methods have been developed, which simultaneously identify and quantitate multiple mycotoxins in foods and feeds. Although matrix effects (matrix-induced ion suppression or enhancement) associated with LC-MS-based mycotoxin analysis remain, this review discusses methods for managing these effects and proposes practical solutions for the future implementation of LC-MS-based multimycotoxin analysis.
美国食品药品监督管理局（FDA）会定期监测霉菌毒素（如黄曲霉毒素、脱氧雪腐镰刀菌烯醇、伏马菌素和展青霉素）的存在情况，以确保其在食品中的浓度低于需要采取监管行动或发布警示的水平。为提高霉菌毒素分析的效率，FDA食品安全与应用营养中心的研究人员一直在评估现代液相色谱-质谱联用（LC-MS）技术。因此，已经开发出了多种液相色谱串联质谱法和液相色谱高分辨率质谱法，可同时鉴定和定量食品及饲料中的多种霉菌毒素。尽管基于LC-MS的霉菌毒素分析中仍存在基质效应（基质诱导的离子抑制或增强），但本综述讨论了管理这些效应的方法，并为未来基于LC-MS的多霉菌毒素分析的实施提出了切实可行的解决方案。
