Fekrazad Reza, Naghdi Nafiseh, Nokhbatolfoghahaei Hanieh, Bagheri Hossein
Laser Research Center in Medical Sciences (LRCMS), Department of Periodontics, Faculty of Dentistry, AJA University of Medical Sciences, Tehran, Iran.
Laser Research Center of Dentistry, Tehran Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
J Lasers Med Sci. 2016 Spring;7(2):62-75. doi: 10.15171/jlms.2016.13. Epub 2016 Mar 27.
Several methods have been employed for cancer treatment including surgery, chemotherapy and radiation therapy. Today, recent advances in medical science and development of new technologies, have led to the introduction of new methods such as hormone therapy, Photodynamic therapy (PDT), treatments using nanoparticles and eventually combinations of lasers and nanoparticles. The unique features of LASERs such as photo-thermal properties and the particular characteristics of nanoparticles, given their extremely small size, may provide an interesting combined therapeutic effect. The purpose of this study was to review the simultaneous application of lasers and metal nanoparticles for the treatment of cancers with epithelial origin. A comprehensive search in electronic sources including PubMed, Google Scholar and Science Direct was carried out between 2000 and 2013. Among the initial 400 articles, 250 articles applied nanoparticles and lasers in combination, in which more than 50 articles covered the treatment of cancer with epithelial origin. In the future, the combination of laser and nanoparticles may be used as a new or an alternative method for cancer therapy or diagnosis. Obviously, to exclude the effect of laser's wavelength and nanoparticle's properties more animal studies and clinical trials are required as a lack of perfect studies.
已经采用了多种方法来治疗癌症，包括手术、化疗和放射治疗。如今，医学科学的最新进展和新技术的发展，导致了新方法的引入，如激素疗法、光动力疗法（PDT）、使用纳米颗粒的治疗方法，以及最终激光与纳米颗粒的联合应用。激光的独特特性，如光热性质，以及纳米颗粒因其极小尺寸而具有的特殊特性，可能会产生有趣的联合治疗效果。本研究的目的是综述激光与金属纳米颗粒同时应用于上皮源性癌症治疗的情况。在2000年至2013年期间，对包括PubMed、谷歌学术和科学Direct在内的电子资源进行了全面搜索。在最初的400篇文章中，有250篇文章将纳米颗粒和激光联合应用，其中50多篇文章涉及上皮源性癌症的治疗。未来，激光与纳米颗粒的联合应用可能会作为一种新的或替代的癌症治疗或诊断方法。显然，由于缺乏完善的研究，需要更多的动物研究和临床试验来排除激光波长和纳米颗粒性质的影响。
